Integration of multi-source gene interaction networks and omics data with graph attention networks to identify novel disease genes
Kaiyuan Yang,
Jiabei Cheng,
Shenghao Cao
et al.
Abstract:The pathogenesis of diseases is closely associated with genes, and the discovery of disease genes holds significant importance for understanding disease mechanisms and designing targeted therapeutics. However, biological validation of all genes for diseases is expensive and challenging. In this study, we propose DGP-AMIO, a computational method based on graph attention networks, to rank all unknown genes and identify potential novel disease genes by integrating multi-omics and gene interaction networks from mu… Show more
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