Integration of Liquid–Liquid Biphasic Flow Alkylation and Continuous Crystallization Using Taylor Vortex Flow Reactors

Hosoya, Masahiro; Tanaka, Masashi; Manaka, Atsushi; Nishijima, Shogo; Tsuno, Naoki

doi:10.1021/acs.oprd.2c00088

Cited by 8 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After a thorough study of conditions to avoid clogging, a long run processing >100 g was achieved, giving the product in 95% yield and >99% purity [116]. The same authors also reported the crystallization of a simple dipeptide with the aim to overcome issues found in batch in relation to product stability and scale-up concerns.…”

Section: Inline Precipitation and Crystallizationmentioning

confidence: 99%

Inline purification in continuous flow synthesis – opportunities and challenges

García-Lacuna¹,

Baumann²

2022

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

Continuous flow technology has become the method of choice for many academic and industrial researchers when developing new routes to chemical compounds of interest. With this technology maturing over the last decades, robust and oftentimes automated processes are now commonly exploited to generate fine chemical building blocks. The integration of effective inline analysis and purification tools is thereby frequently exploited to achieve effective and reliable flow processes. This perspective article summarizes recent applications of different inline purification techniques such as chromatography, extractions, and crystallization from academic and industrial laboratories. A discussion of the advantages and drawbacks of these tools is provided as a guide to aid researchers in selecting the most appropriate approach for future applications. It is hoped that this perspective contributes to new developments in this field in the context of process and cost efficiency, sustainability and industrial uptake of new flow chemistry tools developed in academia.

show abstract

Section: Inline Precipitation and Crystallizationmentioning

confidence: 99%

Inline purification in continuous flow synthesis – opportunities and challenges

García-Lacuna¹,

Baumann²

2022

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

show abstract

“…In this context, we considered that a Taylor vortex flow reactor (TVFR) based on the PFR system could offer a possible solution. TVFR has a simple structure, with the rotation axis generating Taylor vortices at the narrow gap in millimeters between the outer cylinder and the rotation axis, which yields high shear stress and enhances mixing efficiency (Figure a) . The larger cross-sectional area compared with a standard tube reactor is advantageous for mitigating the risk of clogging.…”

Section: Introductionmentioning

confidence: 99%

Application of Taylor Vortex Flow Reactor Enabling Precise Control of Nucleation in Reactive Crystallization

Hosoya,

Manaka,

Kawajiri

et al. 2024

Org. Process Res. Dev.

Self Cite

View full text Add to dashboard Cite

A system that requires slurry handling such as reactive crystallization is not usually compatible with continuous flow synthesis due to the risk of clogging. Here we suggest the use of a Taylor vortex flow reactor to achieve a robust process for imination with reactive crystallization under continuous flow conditions. A Taylor vortex flow reactor realizes high shear stress and mixing efficiency, which accelerate the timing for nucleation of target imines. This effect enabled precise control of nucleation in reactive crystallization and successfully showed the mitigation of significant adhesion to the flow reactor through a long-run experiment for 120 min. This work gives one of the practical strategies to remove the limitation of slurry handling that is not suitable for continuous flow synthesis and increase the performance of flow chemistry.

show abstract

“…35 A process for imine with reactive crystallization in a Taylor vortex flow reactor was achieved due to high mixing efficiency. 36 In recent years, TCR has also been applied to the photocatalytic degradation of pollutants due to its high photon utilization efficiency. However, the current research mainly focuses on the improvements of TCRs on photodegradation efficiency through experiments without dissecting the role of TCRs played in the advancement of HPCT.…”

Section: Introductionmentioning

confidence: 99%

Integrated Taylor–Couette Reactor Model for Heterogeneous Photocatalytic Degradation of AO7

Wang,

Chen,

Wei

et al. 2024

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Taylor−Couette reactors have exhibited great potential for applications in heterogeneous photocatalysis. In this study, an integrated computational fluid dynamic model combining the Euler−Lagrange approach, the discrete ordinate model, the discrete phase model, and the user-defined functions was established to simulate the process of the photocatalytic degradation of acid orange 7 with titanium dioxide and to reveal the interaction among the flow field, radiation field, particle distributions, and reaction kinetics. The results show that an inner cylinder rotation speed of 11.96 rad/s and a light source intensity of over 23 W/m 2 help photocatalysts absorb more photons. The catalysts with a particle size over 300 nm and a mass concentration of 1 g/L give a higher photodegradation efficiency. With the help of this model, heterogeneous photocatalysis technology with Taylor−Couette reactors as the key component can be scaled up for industrial applications in organic pollutant removal.

show abstract

Integration of Liquid–Liquid Biphasic Flow Alkylation and Continuous Crystallization Using Taylor Vortex Flow Reactors

Cited by 8 publications

References 41 publications

Inline purification in continuous flow synthesis – opportunities and challenges

Inline purification in continuous flow synthesis – opportunities and challenges

Application of Taylor Vortex Flow Reactor Enabling Precise Control of Nucleation in Reactive Crystallization

Integrated Taylor–Couette Reactor Model for Heterogeneous Photocatalytic Degradation of AO7

Contact Info

Product

Resources

About