Integration of just‐in‐time learning with variational autoencoder for cell culture process monitoring based on Raman spectroscopy
Mohammad Rashedi,
Hamid Khodabandehlou,
Tony Wang
et al.
Abstract:Protein production in the biopharmaceutical industry necessitates the utilization of multiple analytical techniques and control methodologies to ensure both safety and consistency. To facilitate real‐time monitoring and control of cell culture processes, Raman spectroscopy has emerged as a versatile analytical technology. This technique, categorized as a Process Analytical Technology, employs chemometric models to establish correlations between Raman signals and key variables of interest. One notable approach … Show more
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