Integration of iPSC-Derived Microglia into Brain Organoids for Neurological Research
Muhammad Asif Mrza,
Jitian He,
Youwei Wang
Abstract:The advent of Induced Pluripotent Stem Cells (iPSCs) has revolutionized neuroscience research. This groundbreaking innovation has facilitated the development of three-dimensional (3D) neural organoids, which closely mimicked the intricate structure and diverse functions of the human brain, providing an unprecedented platform for the in-depth study and understanding of neurological phenomena. However, these organoids lack key components of the neural microenvironment, particularly immune cells like microglia, t… Show more
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