Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery

Geetha, P.; Sivaram, Amal J.; Jayakumar, R.; Mohan, C. Gopi

doi:10.1016/j.carbpol.2016.01.059

Cited by 54 publications

(25 citation statements)

References 30 publications

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“…Furthermore, the amount of siRNA transfected into SGC-7901/5-FU cells was less than that into SGC-7901/S cells. This may be because MDR involves increased drug efflux from cancer cells 39 and also increased siRNA efflux. In addition, both naked siRNA and siRNA nanoparticles failed to enter into cells at 4°C, which indicated the uptake was energy-dependent.…”

Section: Discussionmentioning

confidence: 99%

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Co‐delivery of hypoxia inducible factor‐1α small interfering RNA and 5‐fluorouracil to overcome drug resistance in gastric cancer SGC‐7901 cells

Chen

Sun

Guo

et al. 2017

The Journal of Gene Medicine

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Section: Discussionmentioning

confidence: 99%

“…This may be because MDR involves increased drug efflux from cancer cells 39 and also increased siRNA efflux. This may be because MDR involves increased drug efflux from cancer cells 39 and also increased siRNA efflux.…”

Section: Apoptosis Assaymentioning

confidence: 99%

Co‐delivery of hypoxia inducible factor‐1α small interfering RNA and 5‐fluorouracil to overcome drug resistance in gastric cancer SGC‐7901 cells

Chen

Sun

Guo

et al. 2017

The Journal of Gene Medicine

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“…It is worthy to note that although many studies have described drug delivery using polymeric materials, there are very few studies relating the release mechanisms from compressed tablets with the hydrophobicity degree of the polymeric materials and the surface properties of the tablets [ 18 , 19 , 20 ]. For this reason, this work is the continuation of a study focused on establishing relations between the surface thermodynamic properties and in vitro release mechanisms using a model drug (ampicillin trihydrate) as the model and similar polymeric materials with different degrees of hydrophobicity, such as PAM-4Na, PAM-18Na and PAM-18.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Surface Properties and In Vitro Drug Release from Compressed Matrix Containing Polymeric Materials with Different Hydrophobicity Degrees

et al. 2017

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This work is the continuation of a study focused on establishing relations between surface thermodynamic properties and in vitro release mechanisms using a model drug (ampicillin trihydrate), besides analyzing the granulometric properties of new polymeric materials and thus establishing the potential to be used in the pharmaceutical field as modified delivery excipients. To do this, we used copolymeric materials derived from maleic anhydride with decreasing polarity corresponding to poly(isobutylene-alt-maleic acid) (hydrophilic), sodium salt of poly(maleic acid-alt-octadecene) (amphiphilic), poly(maleic anhydride-alt-octadecene) (hydrophobic) and the reference polymer hydroxyl-propyl-methyl-cellulose (HPMC). Each material alone and in blends underwent spectroscopic characterization by FTIR, thermal characterization by DSC and granulometric characterization using flow and compaction tests. Each tablet was prepared at different polymer ratios of 0%, 10%, 20%, 30% and 40%, and the surface properties were determined, including the roughness by micro-visualization, contact angle and water absorption rate by the sessile drop method and obtaining Wadh and surface free energy (SFE) using the semi-empirical models of Young–Dupré and Owens-Wendt-Rabel-Käelbe (OWRK), respectively. Dissolution profiles were determined simulating physiological conditions in vitro, where the kinetic models of order-zero, order-one, Higuchi and Korsmeyer–Peppas were evaluated. The results showed a strong relationship between the proportion and nature of the polymer to the surface thermodynamic properties and kinetic release mechanism.

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“…Chitin is the major component of crustacean (crab [21], lobster [22] and shrimp [23]) shells, the cell walls of fungi [24] and insects [25], and the radulae of Mollusca [26]. The safety of chitin has been proven as a carrier for drug delivery [27]. Chitin can be digested and broken into Chitin Oligosaccharide (COS) by chitinase [28].…”

Section: Introductionmentioning

confidence: 99%

Chitin Oligosaccharide (COS) Reduces Antibiotics Dose and Prevents Antibiotics-Caused Side Effects in Adolescent Idiopathic Scoliosis (AIS) Patients with Spinal Fusion Surgery

Zhou

et al. 2017

Marine Drugs

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Antibiotics are always considered for surgical site infection (SSI) in adolescent idiopathic scoliosis (AIS) surgery. However, the use of antibiotics often causes the antibiotic resistance of pathogens and side effects. Thus, it is necessary to explore natural products as drug candidates. Chitin Oligosaccharide (COS) has anti-inflammation and anti-bacteria functions. The effects of COS on surgical infection in AIS surgery were investigated. A total of 312 AIS patients were evenly and randomly assigned into control group (CG, each patient took one-gram alternative Azithromycin/Erythromycin/Cloxacillin/Aztreonam/Ceftazidime or combined daily), experiment group (EG, each patient took 20 mg COS and half-dose antibiotics daily), and placebo group (PG, each patient took 20 mg placebo and half-dose antibiotics daily). The average follow-up was one month, and infection severity and side effects were analyzed. The effects of COS on isolated pathogens were analyzed. SSI rates were 2%, 3% and 8% for spine wounds and 1%, 2% and 7% for iliac wound in CG, EG and PG (p < 0.05), respectively. COS reduces the side effects caused by antibiotics (p < 0.05). COS improved biochemical indexes and reduced the levels of interleukin (IL)-6 and tumor necrosis factor (TNF) alpha. COS reduced the antibiotics dose and antibiotics-caused side effects in AIS patients with spinal fusion surgery by improving antioxidant and anti-inflammatory activities. COS should be developed as potential adjuvant for antibiotics therapies.

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Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery

Cited by 54 publications

References 30 publications

Co‐delivery of hypoxia inducible factor‐1α small interfering RNA and 5‐fluorouracil to overcome drug resistance in gastric cancer SGC‐7901 cells

Co‐delivery of hypoxia inducible factor‐1α small interfering RNA and 5‐fluorouracil to overcome drug resistance in gastric cancer SGC‐7901 cells

Relationship between Surface Properties and In Vitro Drug Release from Compressed Matrix Containing Polymeric Materials with Different Hydrophobicity Degrees

Chitin Oligosaccharide (COS) Reduces Antibiotics Dose and Prevents Antibiotics-Caused Side Effects in Adolescent Idiopathic Scoliosis (AIS) Patients with Spinal Fusion Surgery

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