Integration of electronic pathology reporting with clinical trial matching for advanced prostate cancer

Borno, Hala; Duffy, Christine; Zhang, Sylvia; Canchola, Alison J.; Loya, Zinnia; Golden, Todd; Oh, Debora L.; Odisho, Anobel Y.; Gomez, Scarlett Lin

doi:10.1016/j.urolonc.2020.12.010

Cited by 4 publications

(16 citation statements)

References 24 publications

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“…Fourteen studies reported aspects impacting the CT participation of mix-age (> = 18 years old) diverse ethnic minority cohorts. 31,34,35,[37][38][39][40]42,43,45,[50][51][52][53] In comparison, 11 studies studied factors associated with older adults (≥65 years old) of diverse ethnic minorities. [28][29][30]32,33,47,[54][55][56][57][58] Five studies focused on discussing factors related to improving or hindering any patient enrollment in CTs.…”

Section: Resultsmentioning

confidence: 99%

“…In seven studies, patients not meeting the clinical trials' eligibility criteria were mentioned as a hindering factor. 29,32,35,36,42,54,56 Reasons may vary; for instance, one study stated that after noticing that Hispanic/Latinx Americans and other ethnic minority groups were more frequently excluded due to their Logical Memory Scores, they adjusted the criteria in an effort to prevent differential exclusion by race and ethnicity. 29 Another study stated that CTs were available for only 7% of Hispanic/ Latina women, compared with 43% for non-Hispanic women.…”

Section: Factors Related To Study Designmentioning

confidence: 99%

“…59 In relation to this, four studies stated low socioeconomic status affected patient enrollment in CTs. 28,35,45,46 For instance, Hispanic/Latinx Americans at lower income levels were associated with being poorly informed about the potential clinical trials and their effects. 45,46 Similarly, a lack of possession or usage of devices, steady internet access, and low-technical literacy were more likely to exclude patients from CTs recruited using online methods.…”

Section: Factors Related To Study Designmentioning

confidence: 99%

“…45,46 Similarly, a lack of possession or usage of devices, steady internet access, and low-technical literacy were more likely to exclude patients from CTs recruited using online methods. 35 Three studies highlighted transportation challenges as hindering aspects. 36,39,42 Four studies report that low education levels could limit Hispanic/Latinx Americans and particularly HLAOA participation in CTs.…”

Section: Factors Related To Study Designmentioning

confidence: 99%

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Factors affecting the recruitment of Hispanic/Latinx American older adults in clinical trials in the United States: A scoping review

Rodriguez

Hewage

Periyakoil

2023

J American Geriatrics Society

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Objective Participation of Hispanic/Latinx American older adults (HLAOA) in clinical trials is fundamental to health equity in aging research. However, information on strategies for the successful recruitment of this population in clinical trials is limited. Design This scoping review aims to identify hindering and facilitating factors that impact the recruitment of HLAOA in clinical trials in the United States. Methods Two databases (PubMed, EMBASE) were searched for original research articles from inception until March 2022 reporting on factors that engaged HLAoa (≥65) in clinical trials. One thousand and thirteen studies were scrutinized to identify 31 eligible articles. Results Most articles were from cancer clinical trials (14 studies). Hindering factors that impacted the recruitment of HLAoa in clinical trials were related to (i) study design and logistics challenges, (ii) challenges imposed by social determinants of health, (iii) communication barriers, and (iv) patients' mistrust, and (v) family issues. Facilitating factors include (i) effective modes of outreach, (ii) strategic clinical trial design, (iii) incorporating culturally‐respectful approaches that are tailored to the participants' sociocultural background, and (iv) bridging language barriers. Conclusions Successful recruitment of HLAOA into clinical trials requires identifying the study question, co‐designing the trial design, implementation, and evaluation in respectful collaboration with the Hispanic/Latinx community with careful attention to their needs and minimizing the study burden on this vulnerable population. Factors identified here may guide researchers to better understand the needs of HLAOA and successfully recruit them into clinical trials, leading to more equitable research that increases their representation in clinical research.

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Section: Resultsmentioning

confidence: 99%

Section: Factors Related To Study Designmentioning

confidence: 99%

Section: Factors Related To Study Designmentioning

confidence: 99%

Section: Factors Related To Study Designmentioning

confidence: 99%

See 2 more Smart Citations

Factors affecting the recruitment of Hispanic/Latinx American older adults in clinical trials in the United States: A scoping review

Rodriguez

Hewage

Periyakoil

2023

J American Geriatrics Society

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“…Trial screening and referral Implicit bias training 46 ; trial matching 47,48 Minimizes bias in trial referral for eligible patients; improves cultural competency of workforce…”

Section: Physicianmentioning

confidence: 99%

Strategies to Advance Equity in Cancer Clinical Trials

Guerra

Fleury

Byatt

et al. 2022

American Society of Clinical Oncology Educational Book

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Cancer clinical trials are critical for testing new treatments, yet less than 5% of patients with cancer enroll in these trials. Minority groups, elderly individuals, and rural populations are particularly underrepresented in cancer treatment trials. Strategies for advancing equity in cancer clinical trials for these populations include (1) optimizing clinical trial matching by broadening eligibility criteria, screening all patients for trial eligibility, expanding the number of trials against which patients are screened, and following up on all patient matches with an enrollment invitation; (2) conducting site self-assessments to identify clinical-, patient-, provider-, and system-level barriers that contribute to low rates of clinical trial screening and enrollment; (3) creating a quality improvement plan that addresses the barriers to enrollment and incorporates the use of tools and strategies such as clinical trial checklists; workforce development and trainings to improve cultural competence and reduce unconscious bias; guides to promote community education, outreach and engagement with cancer clinical trials; screening and accrual logs designed to measure participation by demographics; models of informed consent that improve understanding; clinical trial designs that reduce accessibility barriers; use of cancer clinical trial patient navigators; and programs to eliminate barriers to participation and out-of-pocket expenses; and (4) working with stakeholders to develop both protocols that are inclusive of diverse populations’ geographic locations, and strategies to access those trials. These actions will support greater access for populations that have remained underrepresented in cancer clinical trials and thereby increase the generalizability and efficiency of cancer research.

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Is representation enough or should we be targeting equitable inclusion?

Gomez

Tsai

2022

Nat Rev Clin Oncol

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Integration of electronic pathology reporting with clinical trial matching for advanced prostate cancer

Cited by 4 publications

References 24 publications

Factors affecting the recruitment of Hispanic/Latinx American older adults in clinical trials in the United States: A scoping review

Factors affecting the recruitment of Hispanic/Latinx American older adults in clinical trials in the United States: A scoping review

Strategies to Advance Equity in Cancer Clinical Trials

Is representation enough or should we be targeting equitable inclusion?

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