Integration of EEG Into Psychiatric Practice: A Step Toward Precision Medicine for Autism Spectrum Disorder

Swatzyna, Ronald J.; Tarnow, Jay D.; Turner, Robert P.; Roark, Alexandra J.; MacInerney, Erin K.; Kozlowski, Gerald P.

doi:10.1097/wnp.0000000000000365

Cited by 17 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…163 Other findings support the diagnostic use of EEG in individuals with ASD. 164 For those individuals who have failed prior psychopharmacology attempts, and those who exhibit unusual and challenging behaviours-for example, sudden and unprovoked outbursts of aggression, irritability, crying, screaming or self-harming, unusual facial and body movements and postures, staring spells, covering of ears-an EEG could be helpful for differentiating between seizures and non-epileptic paroxysmal behaviours. 165,166 Metabolic Irregularities, Acquired Mitochondrial Dysfunction and Oxidative Stress in ASD Children and adults with ASD are at significantly greater risk for weight issues and obesity than the general population.…”

Section: Seizure Disorders and Epilepsy In Asdmentioning

confidence: 99%

<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>

Sala¹,

Amet²,

Blagojevic-Stokic³

et al. 2020

NDT

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a highly complex and heterogeneous developmental disorder that affects how individuals communicate with other people and relate to the world around them. Research and clinical focus on the behavioural and cognitive manifestations of ASD, whilst important, have obscured the recognition that ASD is also commonly associated with a range of physical and mental health conditions. Many physical conditions appear with greater frequency in individuals with ASD compared to non-ASD populations. These can contribute to a worsening of social communication and behaviour, lower quality of life, higher morbidity and premature mortality. We highlight some of the key physical comorbidities affecting the immune and the gastrointestinal systems, metabolism and brain function in ASD. We discuss how healthcare professionals working with individuals with ASD and parents/carers have a duty to recognise their needs in order to improve their overall health and wellbeing, deliver equality in their healthcare experiences and reduce the likelihood of morbidity and early mortality associated with the condition.

show abstract

Section: Seizure Disorders and Epilepsy In Asdmentioning

confidence: 99%

<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>

Sala¹,

Amet²,

Blagojevic-Stokic³

et al. 2020

NDT

View full text Add to dashboard Cite

show abstract

“…However, SEAs in patients with ASD exceed those of the general population (ranges from 2% to 8.7%), and this seems to be regardless of age or gender in some studies while in others they seem to decrease with puberty [ 25 , 26 , 27 , 28 ].…”

Section: Seas In Non-epileptic Patients With Asdmentioning

confidence: 99%

Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications

et al. 2020

View full text Add to dashboard Cite

A large body of literature reports the higher prevalence of epilepsy in subjects with Autism Spectrum Disorder (ASD) compared to the general population. Similarly, several studies report an increased rate of Subclinical Electroencephalographic Abnormalities (SEAs) in seizure-free patients with ASD rather than healthy controls, although with varying percentages. SEAs include both several epileptiform discharges and different non-epileptiform electroencephalographic abnormalities. They are more frequently associated with lower intellectual functioning, more serious dysfunctional behaviors, and they are often sign of severer forms of autism. However, SEAs clinical implications remain controversial, and they could represent an epiphenomenon of the neurochemical alterations of autism etiology. This paper provides an overview of the major research findings with two main purposes: to better delineate the state-of-the-art about EEG abnormalities in ASD and to find evidence for or against appropriateness of SEAs pharmacological treatment in ASD.

show abstract

“…Leaving epilepsy aside, it is important not to neglect SEAs, which are present in both epileptic and non-epileptic ASD patients; among the latter, they show a prevalence varying from 8% to 60.7% [ 17 , 60 , 109 , 126 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 ]. This variability is probably due to sampling and methodological heterogeneity in collecting and interpreting EEG tracings [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Children with Autism Spectrum Disorder and Abnormalities of Clinical EEG: A Qualitative Review

Bosetti,

Ferrini,

Ferrari

et al. 2024

JCM

View full text Add to dashboard Cite

Over the last decade, the comorbidity between Autism Spectrum Disorder (ASD) and epilepsy has been widely demonstrated, and many hypotheses regarding the common neurobiological bases of these disorders have been put forward. A variable, but significant, prevalence of abnormalities on electroencephalogram (EEG) has been documented in non-epileptic children with ASD; therefore, several scientific studies have recently tried to demonstrate the role of these abnormalities as a possible biomarker of altered neural connectivity in ASD individuals. This narrative review intends to summarize the main findings of the recent scientific literature regarding abnormalities detected with standard EEG in children/adolescents with idiopathic ASD. Research using three different databases (PubMed, Scopus and Google Scholar) was conducted, resulting in the selection of 10 original articles. Despite an important lack of studies on preschoolers and a deep heterogeneity in results, some authors speculated on a possible association between EEG abnormalities and ASD characteristics, in particular, the severity of symptoms. Although this correlation needs to be more strongly elucidated, these findings may encourage future studies aimed at demonstrating the role of electrical brain abnormalities as an early biomarker of neural circuit alterations in ASD, highlighting the potential diagnostic, prognostic and therapeutic value of EEG in this field.

show abstract

Integration of EEG Into Psychiatric Practice: A Step Toward Precision Medicine for Autism Spectrum Disorder

Cited by 17 publications

References 31 publications

<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>

<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>

Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications

Children with Autism Spectrum Disorder and Abnormalities of Clinical EEG: A Qualitative Review

Contact Info

Product

Resources

About