“…The NEET ASI program anticipates several research needs that will have to be met in order to move advanced reactors from their current state to one in which autonomous operations can be developed, evaluated, and deployed. [2] To meet these needs, the program identified various technologies and methods that facilitate more autonomous operations when integrated into a generic framework for control (Figure 2). These technologies and methods include digital twins (a computational simulation of a process or system that can replicate the behavior of that process or system [3]), machine learning (ML) models, optimization methods, risk modeling, and various types of control methods.…”