2020
DOI: 10.1016/j.xphs.2020.01.016
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Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101

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Cited by 15 publications
(33 citation statements)
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“…Antiretrovirals in DcNP have demonstrated good stability with particles thus protecting them from the native and rapid elimination, while reducing toxic accumulations, such as in the heart or kidney. 90 In vivo, DcNP transformed shortacting drugs that inhibit the HIV protease (lopinavir, ritonavir, atazanavir) and the reverse transcriptase (tenofovir, lamivudine), from half-lives of a few hours into weeks in both mononuclear cells and plasma. 90e93 Hence, DcNP is a subcutaneous delivery platform accommodating combinations of drugs with disparate physiochemical properties (e.g., water-solubility) suitable for transforming multiple daily intakes into a single-dose single-particle injection.…”
Section: Covid-19 Treatment and Long-acting Strategymentioning
confidence: 99%
“…Antiretrovirals in DcNP have demonstrated good stability with particles thus protecting them from the native and rapid elimination, while reducing toxic accumulations, such as in the heart or kidney. 90 In vivo, DcNP transformed shortacting drugs that inhibit the HIV protease (lopinavir, ritonavir, atazanavir) and the reverse transcriptase (tenofovir, lamivudine), from half-lives of a few hours into weeks in both mononuclear cells and plasma. 90e93 Hence, DcNP is a subcutaneous delivery platform accommodating combinations of drugs with disparate physiochemical properties (e.g., water-solubility) suitable for transforming multiple daily intakes into a single-dose single-particle injection.…”
Section: Covid-19 Treatment and Long-acting Strategymentioning
confidence: 99%
“…The a priori plasma-concentration predictions in NHP were carried out by the predictive pharmacokinetic computational modeling (viz. mechanism-based pharmacokinetics, or MBPK (Perazzolo et al, 2020). MBPK is the combination of classical pharmacokinetic modeling with elements describing the main mechanisms working in the system.…”
Section: Setting Up the Mechanism-based Pharmacokinetic Model For Nbimentioning
confidence: 99%
“…SC injections may be more user-friendly to allow the PrEP individual to control their administrations. Additionally, SC administration of nanoparticles may result in more favorable drug pharmacokinetics, particularly, longer release time and better lymphatic targeting (Perazzolo et al, 2018;Perazzolo et al, 2020). nBIC-TAF nanoparticles are made of poly(lactic-coglycolic acid, PLGA) as the main polymer in which BIC and TAF are co-formulated (Mandal et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
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