2020
DOI: 10.3389/fmolb.2019.00155
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Integration of Biological Networks for Acidithiobacillus thiooxidans Describes a Modular Gene Regulatory Organization of Bioleaching Pathways

Abstract: Acidithiobacillus thiooxidans is one of the most studied biomining species, highlighting its ability to oxidize reduced inorganic sulfur compounds, coupled with its elevated capacity to live under an elevated concentration of heavy metals. In this work, using an in silico semi-automatic genome scale approach, two biological networks for A. thiooxidans Licanantay were generated: (i) An affinity transcriptional regulatory network composed of 42 regulatory family genes and 1,501 operons (57% genome coverage) link… Show more

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Cited by 6 publications
(2 citation statements)
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“…A. ferrooxidans and A. thiooxidans present viable candidates for the recovery and bioleaching of P-rich sludge (Cortés et al, 2020). These microorganisms possess the capability to generate sulfuric acid through the oxidation of reduced sulfur compounds, allowing for the establishment of an acidic pH level, potentially below 1.…”
Section: Phosphorusmentioning
confidence: 99%
“…A. ferrooxidans and A. thiooxidans present viable candidates for the recovery and bioleaching of P-rich sludge (Cortés et al, 2020). These microorganisms possess the capability to generate sulfuric acid through the oxidation of reduced sulfur compounds, allowing for the establishment of an acidic pH level, potentially below 1.…”
Section: Phosphorusmentioning
confidence: 99%
“…Systems biology tools that are focused on "omics" data and computational methods, consistently surpass conventional approaches when it comes to metabolic engineering and medium design (Biz et al, 2019;Dangi et al, 2019;Cortés et al, 2020). The comparative advantage of systems biology is related to its accounting for the complex relationship between many components of biological systems (Covert et al, 2004;Basu et al, 2018).…”
Section: Introductionmentioning
confidence: 99%