Hybrid lattice compliant mechanisms (HLCMs) composed of multiple microstructures have attracted widespread interest due to their superior compliant performance compared to the traditional solid compliant mechanisms. A novel optimization scheme for HLCMs is presented using the independent continuous mapping (ICM) method. Firstly, the effective properties of multiple orthogonal and anisotropic lattice microstructures are obtained by taking advantage of homogenization theory, which are used to bridge the relationship between the macrostructure layout and microstructure recognition. Then, a new parallel topology optimization model for optimizing HLCMs is built via a generalized multi-material, recognizing interpolation scheme with filter functions. In addition, the characterization relationship between independent continuous variables and performance of different elements is established. Sensitivity analysis and linear programming are utilized to solve the optimal model. Lastly, numerical examples with a displacement inverter mechanism and compliant gripper mechanism demonstrate the effectiveness of the proposed method for designing HLCMs with various lattice microstructures. Anisotropic lattice microstructures (ALMs) significantly facilitate the efficient use of constitutive properties of materials. Hence, HLCMs consisting of various ALMs achieve superior compliant performance than counterparts comprising different orthogonal lattice microstructures (OLMs). The presented method offers a reference to optimize HLCMs, as well as promotes the theoretical development and application of the ICM method.