Integration of a wireless lock-in measurement of hip prosthesis vibrations for loosening detection

Marschner, Uwe; Grätz, Hagen; Jettkant, Birger; Ruwisch, Dietmar; Woldt, Gregor; Fischer, Wolf‐Joachim; Clasbrummel, B.

doi:10.1016/j.sna.2009.08.025

Cited by 58 publications

(47 citation statements)

References 7 publications

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“…Georgiou and Cunningham [23] also compared vibration analysis with standard radiological assessment and demonstrated that vibration analysis improved diagnostic precision by 20%; moreover, they were able to detect 13% more cases than radiological diagnosis with 81% sensitivity and 89% specificity. Other research groups have used vibration analysis for different orthopaedic applications such as; the telemetry technique to assess THR femoral loosening [24][25][26], trans-femoral osseointegration [27][28][29], intra-operative initial implant stability [6,[30][31][32][33], THR femoral stability utilising acoustic resonance responses [7,[34][35][36][37][38][39][40][41], and complete THR component loosening (femoral and acetabular) [5].…”

Section: Introductionmentioning

confidence: 99%

Development of a non-invasive diagnostic technique for acetabular component loosening in total hip replacements

Alshuhri

Holsgrove

Miles

et al. 2015

Medical Engineering & Physics

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Current techniques for diagnosing early loosening of a total hip replacement (THR) are ineffective, especially for the acetabular component. Accordingly, new, accurate, and quantifiable methods are required. The aim of this study was to investigate the viability of vibrational analysis for accurately detecting acetabular component loosening. A simplified acetabular model was constructed using a Sawbones(®) foam block. By placing a thin silicone layer between the acetabular component and the Sawbones block, 2- and 4-mm soft tissue membranes were simulated representing different loosening scenarios. A constant amplitude sinusoidal excitation with a sweep range of 100-1500 Hz was used. Output vibration from the model was measured using an accelerometer and an ultrasound probe. Loosening was determined from output signal features such as the number and relative strength of observed harmonic frequencies. Both measurement methods were sufficient to measure the output vibration. Vibrational analysis reliably detected loosening corresponding to both 2 and 4 mm tissue membranes at driving frequencies between 100 and 1000 Hz (p < 0.01) using the accelerometer. In contrast, ultrasound detected 2-mm loosening at a frequency range of 850-1050 Hz (p < 0.01) and 4-mm loosening at 500-950 Hz (p < 0.01).

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Section: Introductionmentioning

confidence: 99%

Development of a non-invasive diagnostic technique for acetabular component loosening in total hip replacements

Alshuhri

Holsgrove

Miles

et al. 2015

Medical Engineering & Physics

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“…Especially for systems, which require a wireless communication between implant and control unit outside the human body or a mechanical adaptation of the implant interface to the surrounding tissue, polymer encapsulations are preferred [4][5][6]. Typical examples are retinal implants, neural prostheses, permanent monitoring systems for vital parameters and smart implants.…”

Section: Introductionmentioning

confidence: 99%

Barrier properties of polymer encapsulation materials for implantable microsystems

Kirsten

Wetterling

Uhlemann

et al. 2013

2013 IEEE XXXIII International Scientific Conference Electronics and Nanotechnology (ELNANO)

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Biocompatible polymers utilized for flexible encapsulations of implantable microsystems provide many advantages compared to widely used rigid titanium or ceramic packages. However, polymers alter their properties due to interactions with their environment. As a result the protective function of these materials especially for long-term implants is not reliable. Therefore, we investigated barrier properties against water vapor of silicone and Parylene C membranes. And we combined these polymers to a multi-layer membrane to enhance the protective function of such an encapsulation system. Applying a bonding agent between two polymer layers increases the strength of the sample as well as the barrier properties significantly.

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“…Also, digitizing the analog output of the sensor, which is a small peak carried on a baseline signal which drifts randomly with time, requires a very high resolution and high-end analog-to-digital converter. In the literature, various analog LIA chip architectures have been presented including designs using a single supply, a decrease in supply voltage and power consumption, a reduction in chip area, and exploitation of new architectures to improve performance (Marschner et al 2009;Gnudi et al 1999;Azzolini et al 2008;D'Amico et al 2010;Lee et al 2012;Manickam et al 2012;Kassanos et al 2013;Kassanos et al 2014;Murali et al 2014;Huang and Palermo 2013;Mayahernández et al 2014;Gu and Mcfarlane 2015). Various integrated LIA chips have been developed with a power consumption as low as 207.7 μW (Gu and Mcfarlane 2015) and areas as small as 0.013 mm 2 (Maya-hernández et al 2014).…”

Section: Introductionmentioning

confidence: 99%

A portable battery powered microfluidic impedance cytometer with smartphone readout: towards personal health monitoring

Talukder

Furniturewalla

et al. 2017

Biomed Microdevices

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We present a portable system for personalized blood cell counting consisting of a microfluidic impedance cytometer and portable analog readout electronics, feeding into an analog-to-digital converter (ADC), and being transmitted via Bluetooth to a user-accessible mobile application. We fabricated a microfluidic impedance cytometer with a novel portable analog readout. The novel design of the analog readout, which consists of a lock-in-amplifier followed by a high-pass filter stage for subtraction of drift and DC offset, and a post-subtraction high gain stage, enables detection of particles and cells as small as 1 μm in diameter, despite using a low-end 8-bit ADC. The lock-in-amplifier and the ADC were set up to receive and transmit data from a Bluetooth module. In order to initiate the system, as well as to transmit all of the data, a user friendly mobile application was developed, and a proof-of-concept trial was run on a blood sample. Applications such as personalized health monitoring require robust device operation and resilience to clogging. It is desirable to avoid using channels comparable in size to the particles being detected thus requiring high levels of sensitivity. Despite using low-end off-the-shelf hardware, our sensing platform was capable of detecting changes in impedance as small as 0.032%, allowing detection of 3 μm diameter particles in a 300 μm wide channel. The sensitivity of our system is comparable to that of a high-end bench-top impedance spectrometer when tested using the same sensors. The novel analog design allowed for an instrument with a footprint of less than 80 cm. The aim of this work is to demonstrate the potential of using microfluidic impedance spectroscopy for low cost health monitoring. We demonstrated the utility of the platform technology towards cell counting, however, our platform is broadly applicable to assaying wide panels of biomarkers including proteins, nucleic acids, and various cell types.

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Integration of a wireless lock-in measurement of hip prosthesis vibrations for loosening detection

Cited by 58 publications

References 7 publications

Development of a non-invasive diagnostic technique for acetabular component loosening in total hip replacements

Development of a non-invasive diagnostic technique for acetabular component loosening in total hip replacements

Barrier properties of polymer encapsulation materials for implantable microsystems

A portable battery powered microfluidic impedance cytometer with smartphone readout: towards personal health monitoring

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