Integration of a Three-Dimensional-Printed Titanium Implant in Human Tissues: Case Study

Abstract

A titanium alloy implant of appropriate pore size can potentially enhance osseointegration and soft tissue integration. However, the human clinical application of such implants has not been reported. Here, we present a case of limb salvage surgery for a bone tumor using customized three-dimensional (3D)-printed Ti6Al4V radius and ulna implants. The patient presented with local recurrence at the proximal junction of the ulna and underwent a re-wide excision. Single forearm bone surgery was performed using another 3D-printed implant after resection of the recurrent tumor with an ulnar implant. Host osseointegration and soft tissue integration of the retrieved implant were quantified through histological evaluation. The total tissue integration rates of the implant at the proximal and distal bone junctions were 45.96% and 15.03%, respectively. The mesh structure enhanced bone integration by up to 10.81% in the proximal and by up to 8.91% in the distal bone junction. Furthermore, the soft tissue adhesion rates of the implant shaft were 59.50% and 50.26% in the axial and longitudinal cuts, respectively. No area was left unoccupied throughout the shaft of the implant. Overall, these results indicate that the 3D-printed Ti6Al4V titanium alloy implant with a rough surface has considerable tissue integration ability.

Fabrication of a lattice structure with periodic open pores through three-dimensional printing for bone ingrowth

“…However, a lattice structure, used for securing biocompatibility and bone ingrowth, has poor mechanical property and microstructural weakness 11 , so load bearing can be di cult to achieve with it [1][2][3][4][5] . The bone-inducing ability of the lattice structure with Ti6Al4V has been previously reported in animal experiments and human studies [12][13][14][15] . For example, Fig.…”

Three-Dimensional Printing for Cancer Applications: Research Landscape and Technologies

“…It was found that the new implants posed a lower infection risk, allowed speedy patient recovery and provided a better alternative to traditional prostheses [137]. The same idea was also considered by other research groups helping many patients around the world [138,139].…”

Morphological Evaluation of Tissue Reaction Response to the Titanium Implants for Cranioplasty. Experimental Study

“…Несмотря на значительное количество работ [27][28][29], в основном в области стоматологии, травматологии и ортопедии, по изучению реакции тканей человека и животных [30], а также остеоинтеграции титановых имплантатов [31][32][33], проведение эксперимента было продиктовано необходимостью исследования реакций мягких тканей организма на новые типы изделий, получаемых методом трехмерной печати. В области нейрохирургии изучение морфологических изменений в окружающих имплантат мягких тканях имеет больший приоритет, чем при интеграции имплантата в плоские кости черепа.…”