Integration demands modulate effective connectivity in a fronto-temporal network for contextual sentence integration

Hartwigsen, Gesa; Henseler, Ilona; Stockert, Anika; Wawrzyniak, Max; Wendt, Christin; Klingbeil, Julian; Baumgaertner, Annette; Saur, Dorothee

doi:10.1016/j.neuroimage.2016.08.026

Cited by 23 publications

(28 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The duration of the dip was approximately 600 ms, which suggests that optimal verb retrieval was performed during the dip. The IPFC associated with the frontotemporal network is deactivated during semantic processing and word retrieving [53] [54]. A previous electrocorticogram (ECoG) study revealed that the PCC is also deactivated during semantic processing [55].…”

Section: Cognitive Processes Predicted By the Dip In Er-dba Index Tracementioning

confidence: 93%

Cognitive Control and Brain Network Dynamics during Word Generation Tasks Predicted Using a Novel Event-Related Deep Brain Activity Method

Imai¹,

Katagiri²

2018

JBBS

View full text Add to dashboard Cite

There is a growing interest in the diagnosis and treatment of patients with dementia and cognitive impairment at an early stage. Recent imaging studies have explored neural mechanisms underlying cognitive dysfunction based on brain network architecture and functioning. The dorsal anterior cingulate cortex (dACC) is thought to regulate large-scale intrinsic brain networks, and plays a primary role in cognitive processing with the anterior insular cortex (aIC), thus providing salience functions. Although neural mechanisms have been elucidated at the connectivity level by imaging studies, their understanding at the activity level still remains unclear because of limited time-based resolution of conventional imaging techniques. In this study, we investigated temporal activity of the dACC during word (verb) generation tasks based on our newly developed event-related deep brain activity (ER-DBA) method using occipital electroencephalogram (EEG) alpha-2 powers with a time resolution of a few hundred milliseconds. The dACC exhibited dip-like temporal waveforms indicating deactivation in an initial stage of each trial when appropriate verbs were successfully generated. By contrast, monotonous increase was observed for incorrect responses and a decrease was detected for no responses. The dip depth was correlated with the percentage of success. Additionally, the dip depth linearly increased with increasing slow component of the DBA index at rest across all subjects. These findings suggest that dACC deactivation is essential for cognitive processing, whereas its activation is required for goal-oriented behavioral outputs, such as cued speech. Such dACC functioning, represented by the dip depth, is supported by the activity of the upper brainstem region including monoaminergic neural systems.

show abstract

Section: Cognitive Processes Predicted By the Dip In Er-dba Index Tracementioning

confidence: 93%

Cognitive Control and Brain Network Dynamics during Word Generation Tasks Predicted Using a Novel Event-Related Deep Brain Activity Method

Imai¹,

Katagiri²

2018

JBBS

View full text Add to dashboard Cite

show abstract

“…(B) Regions which have been shown to be associated with semantic control processes in a prior study [21] are employed as cTBS stimulation sites (left aIFG and pMTG) and regions of interest (left aIFG, aMTG and pMTG) for resting-state functional connectivity analysis. Anatomical labels according to AAL2-Toolbox for SPM12.…”

Section: Methodsmentioning

confidence: 99%

“…Neuronavigation was used in order to ensure best spatial accuracy, which is about 5–8 mm [51,52]. Peak coordinates for left aIFG and pMTG from a prior study [21] (see Fig 1B) were transformed to the individual T1 weighted images with SPM8 (Wellcome Trust Centre for Neuroimaging). Brainsight software (version 1.7.6, Rogue Research Inc., Canada) and an infrared tracking system (Polaris Spectra, Northern Digital Inc., Canada) with trackers fixed to the subjects head and the TMS coil were then used to coregister the subjects head and his/her T1 weighted image based on 7 anatomical landmarks allowing for real-time neuronavigation.…”

Section: Methodsmentioning

confidence: 99%

“…Behaviorally, this is reflected by increased reaction times for unexpected or incorrect in relation to expected words in naming or lexical decision tasks [13]. Functional magnetic resonance imaging (fMRI) studies have also shown that such semantic violations are accompanied by increased activity in semantic control networks in left anterior IFG (aIFG), pMTG and additionally anterior middle temporal gyrus (aMTG) [19,20,15,21]. …”

Section: Introductionmentioning

confidence: 99%

“…left aIFG, aMTG and pMTG [21]. We further investigated the relevance of functional connectivity within this network for semantic control processes and finally aimed to modulate this network with the application of continuous theta burst stimulation (cTBS) over left aIFG and pMTG.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fronto-temporal interactions are functionally relevant for semantic control in language processing

et al. 2017

Self Cite

View full text Add to dashboard Cite

Semantic cognition, i.e. processing of meaning is based on semantic representations and their controlled retrieval. Semantic control has been shown to be implemented in a network that consists of left inferior frontal (IFG), and anterior and posterior middle temporal gyri (a/pMTG). We aimed to disrupt semantic control processes with continuous theta burst stimulation (cTBS) over left IFG and pMTG and to study whether behavioral effects are moderated by induced alterations in resting-state functional connectivity. To this end, we applied real cTBS over left IFG and left pMTG as well as sham stimulation on 20 healthy participants in a within-subject design. Stimulation was followed by resting-state functional magnetic resonance imaging and a semantic priming paradigm. Resting-state functional connectivity of regions of interest in left IFG, pMTG and aMTG revealed highly interconnected left-lateralized fronto-temporal networks representing the semantic system. We did not find any significant direct modulation of either task performance or resting-state functional connectivity by effective cTBS. However, after sham cTBS, functional connectivity between IFG and pMTG correlated with task performance under high semantic control demands in the semantic priming paradigm. These findings provide evidence for the functional relevance of interactions between IFG and pMTG for semantic control processes. This interaction was functionally less relevant after cTBS over aIFG which might be interpretable in terms of an indirect disruptive effect of cTBS.

show abstract

Universal neural basis of structure building evidenced by network modulations emerging from Broca's area: The case of Chinese

Zaccarella

Friederici

2018

Human Brain Mapping

View full text Add to dashboard Cite

The basic steps in building up language involve binding words of different categories into a hierarchical structure. To what extent these steps are universal or differ across languages is an open issue. Here we examine the neural dynamics of phrase structure building in Chinese—a language that in contrast to other languages heavily depends on contextual semantic information. We used functional magnetic resonance imaging and dynamic causal modeling to identify the relevant brain regions and their dynamic relations. Language stimuli consisted of syntax‐driving determiners, semantics‐embedded classifiers, and nonverbal symbols making up for two‐component sequences manipulated by the factors structure (phrase/list) and number of words (2‐word/1‐word). Processing phrases compared with word lists elicited greater activation in the anterior part of Broca's area, Brodmann area (BA) 45, and the left posterior superior/middle temporal gyri (pSTG/pMTG), while processing two words against one word led to stronger involvement of the left BA 45, BA 44, and insula. Differential network modulations emerging from subparts of Broca's area revealed that phrasal construction in particular highly modulated the direct connection from BA 44 to left pMTG, suggesting BA 44’s primary role in phrase structure building. Conversely, the involvement of BA 45 rather appears sensitive to the reliance on lexico‐semantic information in Chinese. Against the background of previous findings from other languages, the present results indicate that phrase structure building has a universal neural basis within the left fronto‐temporal network. Most importantly, they provide the first evidence demonstrating that the structure‐building network may be modulated by language‐specific characteristics.

show abstract

Integration demands modulate effective connectivity in a fronto-temporal network for contextual sentence integration

Cited by 23 publications

References 59 publications

Cognitive Control and Brain Network Dynamics during Word Generation Tasks Predicted Using a Novel Event-Related Deep Brain Activity Method

Cognitive Control and Brain Network Dynamics during Word Generation Tasks Predicted Using a Novel Event-Related Deep Brain Activity Method

Fronto-temporal interactions are functionally relevant for semantic control in language processing

Universal neural basis of structure building evidenced by network modulations emerging from Broca's area: The case of Chinese

Contact Info

Product

Resources

About