Integrating multiple omics levels using the human protein complexome as a framework, a multi-omics study of inborn errors of metabolism
Mainak Guharoy,
Isabelle Adant,
Matthew Bird
et al.
Abstract:Proteins organize into functional assemblies that drive diverse biological activities. Leveraging a comprehensive dataset of manually curated annotations for the human protein complexome, we investigated biological perturbations at the protein complex level. Using proteomics and transcriptomics data from fibroblasts of patients with inborn errors of metabolism (IEM) and control samples, we globally mapped information onto complex subunits to discern affected processes. Across the patient cohort (consisting of … Show more
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