Integrating mitochondrial organization and dynamics with cellular architecture

Jayashankar, Vaishali; Rafelski, Susanne M.

doi:10.1016/j.ceb.2013.09.002

Cited by 34 publications

(29 citation statements)

References 42 publications

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“…Mitochondria dynamics is critical for the distribution and maintenance of mitochondrial DNA (mtDNA) [39]. Previous studies have demonstrated that fragmented mitochondria related to mtDNA loss [10], [40].…”

Section: Resultsmentioning

confidence: 99%

Resveratrol Modulates Mitochondria Dynamics in Replicative Senescent Yeast Cells

et al. 2014

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Mitochondria form a reticulum network dynamically fuse and divide in the cell. The balance between mitochondria fusion and fission is correlated to the shape, activity and integrity of these pivotal organelles. Resveratrol is a polyphenol antioxidant that can extend life span in yeast and worm. This study examined mitochondria dynamics in replicative senescent yeast cells as well as the effects of resveratrol on mitochondria fusion and fission. Collecting cells by biotin-streptavidin sorting method revealed that majority of the replicative senescent cells bear fragmented mitochondrial network, indicating mitochondria dynamics favors fission. Resveratrol treatment resulted in a reduction in the ratio of senescent yeast cells with fragmented mitochondria. The readjustment of mitochondria dynamics induced by resveratrol likely derives from altered expression profiles of fusion and fission genes. Our results demonstrate that resveratrol serves not only as an antioxidant, but also a compound that can mitigate mitochondria fragmentation in replicative senescent yeast cells.

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Section: Resultsmentioning

confidence: 99%

Resveratrol Modulates Mitochondria Dynamics in Replicative Senescent Yeast Cells

et al. 2014

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“…Mitochondria function as an intracellular biosensor that responds to environmental changes, stress cues and physiological stimuli (Jayashankar and Rafelski, 2014). Hence, it is very intriguing to test the Myo19 interaction with the mitochondrial network dynamics and morphology in cells under stresses, such as starvation, that induce mitochondrial responses.…”

Section: Glucose Starvation Induced Localization Of Mitochondria and mentioning

confidence: 99%

“…A new function for actin-based motors could emerge as regulators of cellular adaptations to stress, linking actin cytoskeleton remodeling and mitochondria (Jayashankar and Rafelski, 2014). These recent studies demonstrate an essential role for both actin cytoskeleton and myosins for mitochondria function in homeostasis and pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia

Shneyer

Ušaj

Henn

2016

Journal of Cell Science

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Mitochondria respond to environmental cues and stress conditions. Additionally, the disruption of the mitochondrial network dynamics and its distribution is implicated in a variety of neurodegenerative diseases. Here, we reveal a new function for Myo19 in mitochondrial dynamics and localization during the cellular response to glucose starvation. Ectopically expressed Myo19 localized with mitochondria to the tips of starvation-induced filopodia. Corollary to this, RNA interference (RNAi)-mediated knockdown of Myo19 diminished filopodia formation without evident effects on the mitochondrial network. We analyzed the Myo19-mitochondria interaction, and demonstrated that Myo19 is uniquely anchored to the outer mitochondrial membrane (OMM) through a 30-45-residue motif, indicating that Myo19 is a stably attached OMM molecular motor. Our work reveals a new function for Myo19 in mitochondrial positioning under stress.

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“…Given the importance of processes, such as ATP production, Ca 2+ transients, neurotransmitter metabolism and ROS signaling, in synaptic transmission it is not surprising that recent work has illustrated that perturbations in mitochondrial physiology exert profound effects on neuronal development and function. Mitochondrial ATP production, Ca 2+ buffering, neurotransmitter metabolism and ROS signaling themselves are spatially and temporally regulated in neurons through mitochondrial localization (Brodin et al, 1999;Jayashankar and Rafelski, 2014;Li et al, 2004;Niescier et al, 2013;Rueda et al, 2014;Sheng, 2014;Vos et al, 2010), mitochondrial bioenergetics (Rueda et al, 2014;Dickey and Strack, 2011), and mitochondrial biogenesis (Cheng et al, 2012), all of which are strongly influenced by mitochondrial dynamics, which entails mitochondrial fission, fusion and transport.…”

Section: Introductionmentioning

confidence: 99%