Social media is one of the variables affecting sexual behavior among teenagers in today’s society. This study was conducted in Tamale, Ghana, to examine adolescents’ application of social media to access and use reproductive health services. The study involved 342 adolescents randomly selected from multicultural and diverse backgrounds of students drawn from four Senior High Schools in the Tamale metropolis of the Northern Region. Data was collected using semi-structured questionnaires and interview guides. The quantitative data were analyzed using STATA 16.0, chi-square test of association, and binary logistic regression at a 5% significance level. The study found that 45.4% of adolescents accessed reproductive health (RH) information through social media. The study showed that there was a significant association between using a mobile phone to access RH information and romantic relationship (p < 0.001), awareness of reproductive health (p < 0.040), respondents’ place of residence (p < 0.040) and occupation of guardian (p < 0.040), mobile phone ownership (p < 0.004), social media use (p < 0.001), means of accessing RH using a mobile phone (p < 0.02) and whether their problem was solved (p < 0.001). The study concludes that, despite the high utilization of social media and awareness of reproductive health services, less than half (45.4%) of the adolescents use social media by adolescents to access adolescent reproductive health services in the Tamale metropolis.