“…Chemotherapy is often associated with persistent cognitive decline affecting an estimated 78% of patients with non-CNS cancer (Wefel and Schagen, 2012). Neuroimaging studies provide insight regarding the effects of chemotherapy on cognition by demonstrating subtle but diffuse brain injury [see reviews by: (de Ruiter and Schagen, 2013;Kaiser, et al, 2014;Koppelmans, et al, 2013;McDonald and Saykin, 2013;Pomykala, et al, 2013a;Scherling and Smith, 2013;Simo, et al, 2013)].…”