Integrating dynamical modeling and phylogeographic inference to characterize global influenza circulation
Francesco Parino,
Emanuele Gustani-Buss,
Trevor Bedford
et al.
Abstract:Global seasonal influenza circulation involves a complex interplay between local (seasonality, demography, host immunity) and global factors (international mobility) shaping recurrent epidemic patterns. No studies so far have reconciled the two spatial levels, evaluating the coupling between national epidemics, considering heterogeneous coverage of epidemiological and virological data, integrating different data sources. We propose a novel combined approach based on a dynamical model of global influenza spread… Show more
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