Integrating depth of invasion in T classification improves the prognostic performance of the American Joint Committee on Cancer primary tumor staging system for cutaneous squamous cell carcinoma of the head and neck

Amit, Moran; Liu, Chuan; Gleber, Frederico Omar Netto; Kini, Sameer; Tam, Samantha; Benov, Avi; Aashiq, Mohamed; El‐Naggar, Adel K.; Moreno, Amy C.; Rosenthal, D.I.; Glisson, Bonnie S.; Ferrarotto, Renata; Wong, Michael K.; Migden, Michael R.; Li, Guojun; Khanna, Abha; Goepfert, Ryan P.; Nagarajan, Priyadharsini; Weber, Randal S.; Myers, Jeffrey N.; Gross, Neil D.

doi:10.1016/j.ejca.2020.11.019

Cited by 3 publications

(5 citation statements)

References 14 publications

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“…The time to relapse was accelerated with histological ulceration (P = .003) and poor grading (P = .031) of the tumor and neighboring actinic keratoses (P < .001). 18 In the present cohort, patients presented with stage I to III but not metastatic SCC. Considering comorbidities, cardiovascular disorders and diabetes mellitus were the most common.…”

Section: Discussionmentioning

confidence: 67%

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Cutaneous squamous cell carcinoma of head and neck region: A single center analysis of 1296 tumors with clinical characteristics, comorbidities, treatment, and sun‐protection behavior

Warnig

Wollina

2021

Dermatologic Therapy

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Cutaneous squamous cell carcinoma (SCC) is the second most common nonmelanoma skin cancer among Caucasians. We analyzed our data on tumors been treated between 2006 and 2016 at the Skin Cancer Center of an academic teaching hospital. Thousand hundred and ninety-four patients with 1296 SCC have been identified including 804 males (67.3%) and 390 females (32.7%). The mean age among females was significantly higher with (83.9 ± 7.9) years compared with males ([79.3 ± 8.1] years; P < .001). The most common tumor localizations were outer ears (n = 227, 17.5%), scalp (216, 16.7%), and forehead (215, 16.6%). The majority of tumors was stage I. 31.9% of patients had previous SCC or Bowen's cancer, 29.1% had actinic keratoses. Major non-dermatological comorbidities were cardiovascular diseases and diabetes. SCC were treated by delayed Mohs surgery. First Mohs procedure resulted in R0 status in 83.9%. Most cases with R1 resection were located on nose and eyelids. For a subpopulation of patients (n = 105), a structured questionnaire study evaluated changes in sun protection behavior after skin cancer. After the confirmed diagnosis of a cutaneous SCC concerns about harm to the skin by intense sunlight was reported by 78.4% (76) of participants, with 92.0% among females versus 73.6% among males. Eighty percent of females and 76.8% of males wanted to care more about sun-protection in the future, spend less time 84.0% (females) and 72.5% (males) in the sun, and adapt their leisure activities for a better sun protection in 92.0% (females) and 81.9% (males). Secondary prevention in males needs improvement.

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Section: Discussionmentioning

confidence: 67%

“…A recent study identified previous skin cancers as the highest risk for recurrences of cutaneous SCC (RR 3.23). The time to relapse was accelerated with histological ulceration ( P = .003) and poor grading ( P = .031) of the tumor and neighboring actinic keratoses ( P < .001) 18 …”

Section: Discussionmentioning

confidence: 99%

Cutaneous squamous cell carcinoma of head and neck region: A single center analysis of 1296 tumors with clinical characteristics, comorbidities, treatment, and sun‐protection behavior

Warnig

Wollina

2021

Dermatologic Therapy

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“…The Harrell concordance index (C-index) was used to evaluate the performance of the three models [19] , [20] . Bootstrap resampling 1000 times was used to obtain the corrected C-index of the three models for internal verification.…”

Section: Methodsmentioning

confidence: 99%

Value of pre-treatment 18F-FDG PET/CT radiomics in predicting the prognosis of stage III-IV colorectal cancer

Wang

Dai

Zhao

et al. 2023

European Journal of Radiology Open

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“…Several studies have predicted the prognosis of cSCC using T staging systems, such as the American Joint Committee on Cancer (AJCC) and Union for International Cancer Control (UICC) staging systems. [10][11][12] However, the previous versions of AJCC and UICC T staging do not distinctly discriminate and predict patient prognosis. 10,12 Moreover, the current eighth AJCC TNM staging of cSCC is subdivided according to anatomical sites, such as head and neck, lips, eyelids and anogenital area.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the infrequent occurrence of RLNM during the first examination in real‐world clinical practice, prediction of the prognosis of patients with localized cSCC is crucial. Several studies have predicted the prognosis of cSCC using T staging systems, such as the American Joint Committee on Cancer (AJCC) and Union for International Cancer Control (UICC) staging systems 10–12 . However, the previous versions of AJCC and UICC T staging do not distinctly discriminate and predict patient prognosis 10,12 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of prognostic prediction ability of the novel Japanese risk factor scoring system in a Japanese cohort of resectable cutaneous squamous cell carcinoma: A retrospective cross‐sectional study

Doi

Baba

Katô

et al. 2023

Experimental Dermatology

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Japanese patients with very high‐risk cutaneous squamous cell carcinomas (cSCCs), based on the National Comprehensive Cancer Network guidelines, have been reported to display a higher cumulative incidence of relapse and disease‐specific death (DSD) than those with high‐risk cSCC. Therefore, prognosis prediction is crucial for Japanese patients with very high‐risk cSCCs. Herein, we aimed to evaluate the prognostic prediction ability of our novel Japanese Risk Factor Scoring Systems (JARF scoring) in a Japanese cohort of cSSC patients. Data of 424 Japanese patients with resectable very high‐risk cSCCs were analysed. We compared the prognostic ability of the following three staging systems: Brigham and Women's Hospital (BWH) tumour staging, number of NCCN very high‐risk factors, and JARF scoring, including recurrent tumour, high‐risk histological features, deep tumour invasion and lymphatic or vascular involvement as risk factors. The prognostic ability of these staging systems was evaluated according to the cumulative incidence of local recurrence (LR), regional lymph node metastasis (RLNM), DSD, and overall survival (OS). When BWH staging was used, high T stage led to significantly poor outcomes only in the cumulative incidence of RLNM (p = 0.01). The presence of very high‐risk NCCN factors led to significantly poor outcomes in terms of RLNM (p = 0.03) and OS (p = 0.02). Meanwhile, a high number of risk factors in the JARF scoring system clearly led to poor outcomes in terms of LR (p = 0.01), RLNM (p < 0.01), DSD (p = 0.03), and OS (p < 0.01). The JARF scoring system may accurately predict the risk of recurrence and death in very high‐risk cSCC patients in Japan.

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Integrating depth of invasion in T classification improves the prognostic performance of the American Joint Committee on Cancer primary tumor staging system for cutaneous squamous cell carcinoma of the head and neck

Cited by 3 publications

References 14 publications

Cutaneous squamous cell carcinoma of head and neck region: A single center analysis of 1296 tumors with clinical characteristics, comorbidities, treatment, and sun‐protection behavior

Cutaneous squamous cell carcinoma of head and neck region: A single center analysis of 1296 tumors with clinical characteristics, comorbidities, treatment, and sun‐protection behavior

Value of pre-treatment 18F-FDG PET/CT radiomics in predicting the prognosis of stage III-IV colorectal cancer

Evaluation of prognostic prediction ability of the novel Japanese risk factor scoring system in a Japanese cohort of resectable cutaneous squamous cell carcinoma: A retrospective cross‐sectional study

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