Automated shuttle buses entail adopting new technologies and modifying users’ practices, cultural and symbolic meanings, policies, and markets. This results in a paradigmatic transition for a typical sociotechnical system: the transport system. However, the focus of the extant literature often lacks an overall vision, addressing a single technology, supply chain, or societal dimension. Although systemic design can manage multiple-level and long-term transitions, the literature does not discuss how systemic design tools can support implementation. This paper takes the four strategies proposed by Pereno and Barbero in 2020 as the theoretical framework to fill this literature gap, discussing the specific systemic design methods applicable to the design of automated shuttle bus systems. A six-week workshop to facilitate the exploration of future autonomous public transportation is taken as a case study. The systemic design approach was applied to enrich the Human–Machine Interaction (HMI) and functional architecture of automated shuttle buses.