Integrating Computational Methods in Network Pharmacology and In Silico Screening to Uncover Multi-targeting Phytochemicals against Aberrant Protein Glycosylation in Lung Cancer
Abstract:Glycoproteins are an underexploited drug target for cancer
therapeutics.
In this work, we integrated computational methods in network pharmacology
and in silico docking approaches to identify phytochemical
compounds that could potentially interact with several cancer-associated
glycoproteins. We first created a database of phytochemicals from
selected plant species, Manilkara zapota (sapodilla/chico), Mangifera indica (mango), Annona muricata (soursop/guyabano), Artocarpus heterophyllus (jackfruit/langka), Lan… Show more
Aberrant glycosylation induced by LPS in the microglial glycocalyx can be restored by dietary and gut microbe-derived fatty acids highlighting their potential to relieve neuroinflammation.
Aberrant glycosylation induced by LPS in the microglial glycocalyx can be restored by dietary and gut microbe-derived fatty acids highlighting their potential to relieve neuroinflammation.
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