Integrating Clinical Information in National Biobank of Korea

Abstract

The National Biobank of Korea (NBK) is a government supported project that aims at consolidating various human-originated biomedical resources collected by individual hospitals nation-wide and integrating them with their donors' clinical information which researchers can take advantage of. In this paper, we present our experiences in developing the Clinical Information Integration System (CIIS) for NBK. The system automatically extracts clinical data from hospital information systems as much as possible to avoid errors from manual entry by human errors. It maintains the independence of individual hospitals by employing a two-layer approach, one of which takes care of all hospital-specific aspects. Interoperability is achieved by adopting HL7 v2.x messaging between the biobank and hospitals. We report the current status of the biobank and system deployments. We finally identify limitations and discuss how to improve them.

Embedding the shapes of regions of interest into a Clinical Document Architecture document

“…The method was used to develop an application by IHIS Lab (http://giant.knu.ac.kr) in August 2011 and is combined with CDA Generator [11][12][13][14] to generate CDA documents. In this section, we report the results concerning the implementation as of December 2012.…”

“…In contrast, most other available systems 11,[16][17][18][19][20][21][22][23] worldwide focus more on how to generate, register, and manage a CDA document for exchange. Furthermore, such systems may focus on CDA compatibility with an existing local standard for a country with less emphasis on the implementation of CDA across a wide spectrum of systems in order to improve the effects of CDA.…”

“…(c) Since CDA Generator takes care of access to databases, our method is independent of the data source; and finally (d) the clinical document content and ROI shapes can be rendered by the web browser of choice without requiring a special viewer. 18,19 Developing an authoring tool to generate CDA documents No EGADSS 20 Opening interface for medical data exchange No Referral letter system 21 Adapting CDA R2 with local standards to make a Japanese medical data exchange standard No Portable CDA system 22 Sharing clinical documents in an offline model Only medical images, but not ROIs CIIS 11 Collecting clinical information from hospitals nationwide to store in regional Biobanks and then exchanging clinical data from BIS to researchers using CDA No MIES 23 Sharing medical information based on CDA No CDA integration system Improving the effects of CDA to enhance the exchange of the shapes of ROIs and also to exchange clinical documents Virtually and directly rendering all information to a recipient PDA: personal digital assistant; HIS: hospital information system; CDA: Clinical Document Architecture; EHR: electronic health record; EGADSS: evidence-based guidelines and decision support system; CDA R2: Clinical Document Architecture Release 2; ROI: region of interest; CIIS: clinical information integration system; BIS: biobank information system; MIES: medical information exchange system.…”

Data Sharing Challenges and Recommendations for Human Biorepositories: A Systematic Literature Review

“…In integrating clinical information from the National biobank of Korea, thirty-one common data elements are associated with all types of dise ases. However, five out of thirtyone common data elements could not be integrated automatically as they are in fre e text format which seems to be a major problem in inte grating data from multiple systems [17] .…”

Genome technologies and personalized dental medicine

“…Similarly, it is possible to establish a national dental biobank, or add a dental section to existing biobanks, with the contribution of specimens from private and public clinics and hospitals across the United States. This can be facilitated by forming a network structure to alleviate the magnitude of such a project (Kim et al , 2011).…”