Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project

Benet, Marta; Albang, Richard; Pinart, Mariona; Hohmann, Cynthia; Tischer, Christina; Annesi‐Maesano, Isabella; Baïz, Nour; Bindslev‐Jensen, Carsten; Carlsen, Karin C. Lødrup; Cirugeda, Lourdes; Eller, Esben; Fantini, Maria Pia; Gehring, Ulrike; Gerhard, Beatrix; Gori, Davide; Hallner, Eva; Kull, Inger; Lenzi, Jacopo; McEachan, Rosemary; Минина, Е С; Momas, Isabelle; Narduzzi, Silvia; Petherick, Emily; Porta, Daniela; Rancière, Fanny; Standl, Marie; Torrent, Maties; Wijga, Alet H.; Wright, John; Kogevinas, Manolis; Guerra, Stefano; Sunyer, Jordi; Keil, Thomas; Bousquet, Jean; Maier, Dieter; Antó, Josep M.; Garcia‐Aymerich, Judith

doi:10.1093/aje/kwy242

Cited by 13 publications

(8 citation statements)

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“…For the present analyses, IPD from the five oldest birth cohorts participating in the MeDALL project (BAMSE: Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology, PIAMA: Prevention and Incidence of Asthma and Mite Allergy, GINIplus: German Infant Nutritional Intervention-Program, LISA: Lebensstil, Immunsystem, Allergien and MAS: Multizentrische Allergie Studie4) from three European countries (Sweden, the Netherlands and Germany) with follow-up assessments up to 20 years of age were used. Data from the five cohorts were combined by consistent harmonisation rules and processes,5 6 while data from the most recent follow-up were derived from a common harmonised MeDALL Core Questionnaire for four of the five birth cohorts 7. A detailed description of the overall MeDALL collaboration8 9 and the inclusion and exclusion criteria of the birth cohorts for the current analysis have been reported previously 3…”

Section: Methodsmentioning

confidence: 99%

Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL

et al. 2019

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IntroductionTo understand the puberty-related sex shift in the prevalence of asthma and rhinitis as single entities and as respiratory multimorbidities, we investigated if there is also a sex-specific and puberty-related pattern of their incidences.MethodsWe used harmonised questionnaire data from 18 451 participants in five prospective observational European birth cohorts within the collaborative MeDALL (Mechanisms of the Development of Allergy) project. Outcome definitions for IgE-associated and non-IgE-associated asthma, rhinitis and respiratory multimorbidity (first occurrence of coexisting asthma and rhinitis) were based on questionnaires and the presence of specific antibodies (IgE) against common allergens in serum. For each outcome, we used proportional hazard models with sex–puberty interaction terms and conducted a one-stage individual participant data meta-analysis.ResultsGirls had a lower risk of incident asthma (adjusted HR 0.67, 95% CI 0.61 to 0.74), rhinitis (0.73, 0.69 to 0.78) and respiratory multimorbidity (0.58, 0.51 to 0.66) before puberty compared with boys. After puberty onset, these incidences became more balanced across the sexes (asthma 0.84, 0.64 to 1.10; rhinitis 0.90, 0.80 to 1.02; respiratory multimorbidity 0.84, 0.63 to 1.13). The incidence sex shift was slightly more distinct for non-IgE-associated respiratory diseases (asthma 0.74, 0.63 to 0.87 before vs 1.23, 0.75 to 2.00 after puberty onset; rhinitis 0.88, 0.79 to 0.98 vs 1.20, 0.98 to 1.47; respiratory multimorbidity 0.66, 0.49 to 0.88 vs 0.96, 0.54 to 1.71) than for IgE-associated respiratory diseases.DiscussionWe found an incidence ‘sex shift’ in chronic respiratory diseases from a male predominance before puberty to a more sex-balanced incidence after puberty onset, which may partly explain the previously reported sex shift in prevalence. These differences need to be considered in public health to enable effective diagnoses and timely treatment in adolescent girls.

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Section: Methodsmentioning

confidence: 99%

Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL

et al. 2019

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“…However, because the working group was formed as the Network began, it has been possible to prospectively define a minimum core set of common data elements across the clinical trials [ 20 , 21 ] that will allow for rapid dissemination of cross-network patient characteristics. The working group finalized this core set of data elements iteratively, through multiple rounds of discussion during the protocol and database development phases [ 22 ] .…”

Section: Working Groups and Their Productsmentioning

confidence: 99%

Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network

Ginsburg

Cavallari

Chakraborty

et al. 2021

Genetics in Medicine

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Purpose: A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions. Methods: The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions; to assess approaches for real-world application of genomic medicine in diverse clinical settings; and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation. Results: Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk APOL1 variants in African Americans in the management of their hypertension, and the other to evaluate the use of pharmacogenetic testing for medications to manage acute and chronic pain as well as depression. Conclusions: IGNITE PTN is the first network to carry out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions. IGNITE PTN will develop the evidence to support (or oppose) the adoption of genomic medicine interventions by patients, providers, and payers.

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“…Second, existing historical data from fourteen birth cohorts, including three to twenty follow-ups, from nine European countries were harmonised 19 . The harmonisation process followed six steps: an expert panel; identification of candidate variables; an agreed reference definition for each candidate variable; assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of the inferential equivalence as complete, partial, or impossible; a workshop to agree on the reference definitions and classifications of inferential equivalence; and, data preparation and delivery through a knowledge management portal.…”

Section: Medall Strategy To Integrate Heterogeneous Data From Differementioning

confidence: 99%

Mechanisms of the Development of Allergy (MeDALL) Study: A Systems Medicine Approach to Understand Allergic Diseases

Antó¹,

Bousquet²

2021

BRN

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Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project

Cited by 13 publications

References 50 publications

Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL

Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL

Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network

Mechanisms of the Development of Allergy (MeDALL) Study: A Systems Medicine Approach to Understand Allergic Diseases

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