Integrating bipolar electrochemistry and electrochemiluminescence imaging with microdroplets for chemical analysis

Wu, Suozhu; Zhou, Zhenyu; Xu, Linru; Su, Bin; Fang, Qun

doi:10.1016/j.bios.2013.09.042

Cited by 76 publications

(41 citation statements)

References 40 publications

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“…Similar to conventional ECL, WL-ECL has also recently been used for a variety of sensing and screening applications [25][26][27]. Within previous reports [28][29][30][31][32][33], however, the application evaluation of C-WL-ECL techniques using real samples is relatively rare. In the present case, four real samples including water, milk, human urine and human serum were used to verify the applicability and validity of the established method.…”

Section: Application To Real Samplesmentioning

confidence: 99%

“…The WL-ECL can be performed in either an open or a closed BPE form [27]. For the previously reported C-WL-ECL, BPEs are usually set up in microfluidic devices [28][29][30][31][32][33]. Since its introduction in 2012 [28], WL-ECL using a closed BPE (C-WL-ECL) has become increasingly attractive, possibly due to its unique advantage of physical separation of two poles of BPE.…”

Section: Introductionmentioning

confidence: 99%

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A low-cost, ultraflexible cloth-based microfluidic device for wireless electrochemiluminescence application

Liu

Wang

et al. 2016

Lab Chip

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The rising need for low-cost diagnostic devices has led to the search for inexpensive matrices that allow performing alternative analytical assays. Cloth is a viable material for the development of analytical devices due to its low material and manufacture costs, ability to wick assay fluids by capillary forces, and potential for patterning multiplexed channel geometries. In this paper, we describe the construction of low-cost, ultraflexible microfluidic cloth-based analytical devices (μCADs) for wireless electrochemiluminescence based on closed bipolar electrodes (C-WL-ECL), employing extremely cheap materials and a manufacturing process. The C-WL-ECL μCADs are built with wax-screen-printed cloth channels and carbon ink screen-printed electrodes, and the estimated cost per device is only $0.015. To demonstrate the performance of C-WL-ECL μCADs, the two most commonly used ECL systems - tris(2,2'-bipyridyl)ruthenium(ii)/tri-n-propylamine (Ru(bpy)3(2+)/TPA) and 3-aminophthalhydrazide/hydrogen peroxide (luminol/H2O2) - are applied. Under optimized conditions, the C-WL-ECL method has successfully fulfilled the quantitative determination of TPA with a detection limit of 0.085 mM. In addition, on the bent μCADs (bending angle (θ) = 180°), the luminol/H2O2-based ECL system can detect H2O2 as low as 0.024 mM. Based on such an ECL system, the bent μCADs are further used for determination of glucose in a phosphate buffer solution (PBS), with the detection limit of 0.195 mM. Finally, the applicability and validity, anti-interference ability, and storage stability of the C-WL-ECL μCADs are investigated. The results indicate that the proposed device has shown potential to extend the use of microfluidic analytical devices, due to its simplicity, low cost, ultraflexibility, and acceptable analytical performance.

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Section: Application To Real Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A low-cost, ultraflexible cloth-based microfluidic device for wireless electrochemiluminescence application

Liu

Wang

et al. 2016

Lab Chip

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“…Also, the use of conventional ECL reagents is restricted by their excessive price and difficulty to dispose of. Researchers have paid efforts in saving ECL reagents by immobilizing ECL reagents on electrodes and designing new structures of reagent-saving electrochemical cells such as indium tin oxide(ITO)-based [20,21] and paperbased [22,23] chips. Besides, finding cost-effective alternatives as ECL reagents is also a good method.…”

Section: Introductionmentioning

confidence: 99%

Development of Miniaturized Electrochemiluminescence Instrument using Multi‐pixel Photon Counter as the Optical Detector

Dai

Zhao

et al. 2020

Electroanalysis

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We developed a miniaturized electrochemiluminescence (ECL) instrument coupled with a light‐emitting diode‐based bipolar electrochemical sensor (LED‐BPES). This instrument composes of a microcontroller circuit, a power supply circuit, a potentiostat, an optical detecting circuit, and a communication circuit. The multi‐pixel photon counter (MPPC), which is low‐cost, small‐size, and wide‐range in optical measurements, is chosen as the optical detector. The LED‐BPES composes of a disposable screen‐printed carbon electrode (SPCE) and a surface‐mount red LED. Depended on the closed bipolar electrode (C‐BPE) structure, the LED‐BPES not only avoids the employment of unstable and complex ECL reactions but also offers a cost‐effective alternative for the over‐priced ECL reagents by using a mini‐size commercial LED as the luminescent producer. The combination of MPPC and LED‐BPES helps to set up the simplified and downsized instrument system with low price and high efficiency. The presented instrument coupled with LED‐BPES works excellent in electroactive molecules detection and has great potential in the application of heavy metal ions detection.

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“…Since the 1960s, ECL has expanded to a variety of analytical applications [7], including biological analyses [8][9][10][11][12], cancer biomarker detection [13], and cell surface characterization [14]. In such applications, ECL has advantages over traditional detecting techniques because it does not require a light source [2,5].…”

Section: Introductionmentioning

confidence: 99%

Comparison study of electrochemiluminescence of boron-dipyrromethene (BODIPY) dyes in aprotic and aqueous solutions

Chauhan

Chu

Yan

et al. 2016

Journal of Electroanalytical Chemistry

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Integrating bipolar electrochemistry and electrochemiluminescence imaging with microdroplets for chemical analysis

Cited by 76 publications

References 40 publications

A low-cost, ultraflexible cloth-based microfluidic device for wireless electrochemiluminescence application

A low-cost, ultraflexible cloth-based microfluidic device for wireless electrochemiluminescence application

Development of Miniaturized Electrochemiluminescence Instrument using Multi‐pixel Photon Counter as the Optical Detector

Comparison study of electrochemiluminescence of boron-dipyrromethene (BODIPY) dyes in aprotic and aqueous solutions

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