Integrating Bioinformatics and Machine Learning to Investigate the Mechanisms by Which Three Major Respiratory Infectious Diseases Exacerbate Heart Failure
Yiding Yu,
Juan Zhang,
Jingle Shi
et al.
Abstract:BackgroundHeart failure (HF) is a severe cardiovascular disease often worsened by respiratory infections like influenza, COVID-19, and community-acquired pneumonia (CAP). This study aims to uncover the molecular commonalities among these respiratory diseases and their impact on HF, identifying key mediating genes.MethodsDatasets from the GEO database were analyzed for differential expression to find common molecular features of the three respiratory diseases. Weighted Gene Co-expression Network Analysis (WGCNA… Show more
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