A change of mass or temperature, or an applied force causes a response of a mechanical resonator. The response can, e.g., be a change in frequency or vibrational amplitude. The responsivity of a mechanical resonator is the linear slope of the response to a particular stimulant. In case of a sensor application, the responsivity to the input parameter to be measured should be maximal. However, the responsivity to other inputs, such as a change in ambient temperature, should be minimal in order not to cause an unwanted cross-response. In this chapter, the responsivities of micro and nanomechanical resonators to mass (distributed and point masses), forces, and temperature are discussed.