Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina

Abstract

Mice have emerged as a widely employed model for investigating various retinal diseases. However, the availability of comprehensive datasets capturing the entire developmental and aging stages of the mouse retina, particularly during the elderly period, encompassing integrated lncRNA and mRNA expression profiles, is limited. In this study, we assembled a total of 18 retina samples from mice across 6 distinct stages of development and aging (5 days, 3 weeks, 6 weeks, 10 weeks, 6 months, and 15 months) to conduct integrated lncRNA and mRNA sequencing analysis. This invaluable dataset offers a comprehensive transcriptomic resource of mRNA and lncRNA expression profiles during the natural progression of retinal development and aging. The discoveries stemming from this investigation will significantly contribute to the elucidation of the underlying molecular mechanisms associated with various retinal diseases, such as congenital retinal dysplasia and retinal degenerative diseases.

Multiple transcriptome analyses reveal mouse testis developmental dynamics

“…Séverine et al [ 46 ] described the miRNA expression profile during early post-natal skeletal muscle growth in mice, and the miRNA expression trends were essentially the same. The lncRNAs and mRNAs in the mouse retina also showed non-random expression status across six developmental stages [ 47 , 48 ]. Similar results can also been found in developing mouse brain [ 49 ] and stomach [ 50 ].…”