Integrated toxic evaluation of sulfamethazine on zebrafish: Including two lifespan stages (embryo-larval and adult) and three exposure periods (exposure, post-exposure and re-exposure)

Yan, Zhengyu; Yang, Qiulian; Jiang, Weili; Lu, Jilai; Xiang, Zhongrun; Guo, Ruixin; Chen, Jianqiu

doi:10.1016/j.chemosphere.2017.12.119

Cited by 47 publications

(11 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The up-regulation of mRNA levels of several key proinflammatory cytokines and their corresponding proteins, including interleukin-1β (IL-1β), interferon-γ (IFN-γ) and interleukin-11 (IL-11), was observed after 120 h of sulfamethoxazole exposure, as well as the interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) displaying a dose-response relationship. Interestingly, Chen et al [ 94 ] considered two lifespan stages (embryo and adult) and three exposure periods (exposure, post- and re-exposure) in order to analyze the effects induced by sulfamethazine. The results suggested that sulfamethazine can induce side effects in both embryos and adult zebrafish.…”

Section: Effects Of Individual Antibiotics In Zebrafishmentioning

confidence: 99%

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics

et al. 2021

View full text Add to dashboard Cite

The overuse of antibiotics combined with the limitation of wastewater facilities has resulted in drug residue accumulation in the natural environment. Thus, in recent years, the presence of antibiotic residues in the environment has raised concerns over the potential harmful effects on ecosystems and human health. The in vivo studies represent an essential step to study the potential impact induced by pharmaceutical exposure. Due to the limitations of traditional vertebrate model systems, zebrafish (Danio rerio) has recently emerged as a promising animal model to study the toxic effects of drugs and their therapeutic efficacy. The present review summarizes the recent advances made on the toxicity of seven representative classes of antibiotics, namely aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides, tetracyclines and polyether antibiotics, in zebrafish, as well as the combined effects of antibiotic mixtures, to date. Despite a significant amount of the literature describing the impact of single antibiotic exposure, little information exists on the effects of antibiotic mixtures using zebrafish as an animal model. Most of the research papers on this topic have focused on antibiotic toxicity in zebrafish across different developmental stages rather than on their efficacy assessment.

show abstract

Section: Effects Of Individual Antibiotics In Zebrafishmentioning

confidence: 99%

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Soil contamination by antibiotics is associated with the application of antibiotic-contaminated manures and wastewater irrigation. (Continued ) crustaceans (e.g., Daphnia magna), fish (e.g., Oryzias melastigma and Danio rerio) [34,[64][65][66][67][68][69][70]. As shown by the obtained EC50 values, the toxicity of antibiotics varies depending on test organisms and antibiotic types.…”

Section: Manure and Soilmentioning

confidence: 99%

“…Other adverse effects of antibiotics on physiology of fish include the change of biomarkers activities (e.g., acetylcholinesterase, SOD, CAT, MDA, glutathione peroxidase, and glutathione S-transferase), developmental toxicity (reflecting as embryo malformations, hatchability decrease, etc. ), and functional disorders of nervous system [ 66 , 68 , 70 , 79 , 80 ]. Toxicity effects of antibiotic residues on the reproduction and development of fish have attracted much attention.…”

Section: Toxicity and Effectsmentioning

confidence: 99%

“…To date, most studies have examined the effects of a single antibiotic on aquatic organisms, including ERY on Microcystis flos-aquae [ 75 ], AMX on Microcystis aeruginosa [ 82 ], TC on ciliates [ 69 ], NOR on Cyprinus carpio [ 70 ], SMZ on Oryzias melastigma [ 66 ], Zebrafish [ 68 ] and others [ 83 , 84 ]. However, because different categories of antibiotics are released into environmental matrices, aquatic organisms are always exposed to mixtures of antibiotics.…”

Section: Toxicity and Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods

et al. 2021

Self Cite

View full text Add to dashboard Cite

Antibiotics, as antimicrobial drugs, have been widely applied as human and veterinary medicines. Recently, many antibiotics have been detected in the environments due to their mass production, widespread use, but a lack of adequate treatment processes. The environmental occurrence of antibiotics has received worldwide attention due to their potential harm to the ecosystem and human health. Research status of antibiotics in the environment field is presented by bibliometrics. Herein, we provided a comprehensive overview on the following important issues: (1) occurrence of antibiotics in different environmental compartments, such as wastewater, surface water, and soil; (2) toxicity of antibiotics toward non-target organisms, including aquatic and terrestrial organisms; (3) current treatment technologies for the degradation and removal of antibiotics, including adsorption, hydrolysis, photodegradation and oxidation, and biodegradation. It was found that macrolides, fluoroquinolones, tetracyclines, and sulfonamides were most frequently detected in the environment. Compared to surface and groundwaters, wastewater contained a high concentration of antibiotic residues. Both antibiotics and their metabolites exhibited toxicity to non-target organisms, especially aquatic organisms (e.g., algae and fish). Fluoroquinolones, tetracyclines, and sulfonamides can be removed through abiotic process, such as adsorption, photodegradation, and oxidation. Fluoroquinolones and sulfonamides can directly undergo biodegradation. Further studies on the chronic effects of antibiotics at environmentally relevant concentrations on the ecosystem were urgently needed to fully understand the hazards of antibiotics and help the government to establish the permissible limits. Biodegradation is a promising technology; it has numerous advantages such as cost-effectiveness and environmental friendliness.

show abstract

“…But in what concerns CTP/MTP, few studies analyzed post-exposure effects in D. magna. In previous studies, Yan et al (2018) revealed that after 7days of exposed-recovery to sulfamethazine (SMZ), the activities of SOD and MDA of zebra sh were reversed. However, after 1-week of exposed-recovery to rifampicin, bacterial communities of Gambusia a nis were not able to recover in terms of diversity or composition (Carlson et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Ma¹,

Li²,

Wei³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Citalopram (CTP) and mirtazapine (MTP) are two typical psychoactive drugs used for the treatment of depression. As emerging pollutants, CTP and MTP are of widely concern because they are active substances for organisms. However, the studies about the toxicity potential of CTP/MTP pollution to aquatic organisms were limited. In the present study, the effects of CTP and MTP on the feeding behavior, heartbeat, nutritional enzymes and related gene expressions of Daphnia magna were investigated under single and mixed environmental stress. Meanwhile, the recovery of exposed D. magna was studied to analyze the toxic persistence of those pollutants. After 24 h of exposure, the ingestion rate decreased significantly under 1.45 mg/L of CTP. In the mixed treatment groups, no significant synergistic effect of CTM and MTP on daphnia’ feeding inhibition was found. After 24 h of recovery, the feeding behavior of D. magna was stimulated by compensatory stimulation. At exposure period, the heartbeat rate of exposed D. magna increased significantly, and was recovered during the recovery period. The activity of α-amylase (AMS) and trypsin, and their relative gene expression were significantly changed in most of the exposed daphnia, both in the exposure period and recovery period. But there were different responses between gene transcription with enzyme activity. In general, psychoactive drugs have an obvious toxic threat to aquatic organisms, and after acute exposure, the physiological function of D. magna could be recovered to a certain extent. The results were helpful to evaluate the ecological risk of psychotropic drugs in aquatic environments.

show abstract

Integrated toxic evaluation of sulfamethazine on zebrafish: Including two lifespan stages (embryo-larval and adult) and three exposure periods (exposure, post-exposure and re-exposure)

Cited by 47 publications

References 42 publications

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics

Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Contact Info

Product

Resources

About