2013
DOI: 10.1002/jat.2943
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Integrated testing and assessment approaches for skin sensitization: a commentary

Abstract: A Bayesian integrated testing strategy (ITS) approach, aiming to assess skin sensitization potency, has been presented, in which data from various types of in vitro assays are integrated and assessed in combination for their ability to predict in vivo skin sensitization data. Here we discuss this approach and compare it to our quantitative mechanistic modeling (QMM) approach based on physical organic chemistry. The main findings of the Bayesian study are consistent with our chemistry-based approach and our pre… Show more

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Cited by 10 publications
(13 citation statements)
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“…ITS potency assessment approaches developed to date include 3-way and 4-way LLNA EC3 deterministic classification [19][20][21], pEC3 (molar equivalent of EC3) prediction [22][23][24], 4-way probabilistic EC3 classification [25][26][27] and 4-way probabilistic pEC3 classification with a possibility to estimate any percentile of pEC3 distribution [28]. All other ITS approaches mentioned in this mini-review are for hazard estimation only.…”
Section: Its Approaches State Of the Artmentioning
confidence: 99%
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“…ITS potency assessment approaches developed to date include 3-way and 4-way LLNA EC3 deterministic classification [19][20][21], pEC3 (molar equivalent of EC3) prediction [22][23][24], 4-way probabilistic EC3 classification [25][26][27] and 4-way probabilistic pEC3 classification with a possibility to estimate any percentile of pEC3 distribution [28]. All other ITS approaches mentioned in this mini-review are for hazard estimation only.…”
Section: Its Approaches State Of the Artmentioning
confidence: 99%
“…Approaches based on machine learning algorithms are very popular. Among them are linear regression regression-based methods [23,24,30] and nonlinear methods like neural networks [19,20], support vector machines [31] and random-forest models [27].…”
Section: Its Approaches State Of the Artmentioning
confidence: 99%
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