Integrated stochastic modeling of pharmaceuticals in sewage networks

Modelling the fate of micropollutants in integrated urban wastewater systems: Extending the applicability to pharmaceuticals

“…The classical consumption-excretion conceptualization proposed by Khan and Ongerth (2004) and Coutu et al (2016), using a limited number of model parameters, was extended by including new excretion pathways (Figure 1). Local consumption data were used to derive the total ingested PhAC mass (M ingested ), which is then excreted through urine (M MP,urine ), feces (M MP,feces ), and as glucuronide conjugates (M MP,conj,gluc ).…”

“…These characteristics lead to high variability in wastewater concentrations (Luo et al, 2014;Margot et al, 2015). Different studies included different PhACs release models in simple mass balance calculations (Letsinger and Kay, 2019;Ashton et al, 2004), or in more sophisticated models (Khan and Ongerth, 2004;Coutu et al, 2016). Dynamic PhAC release patterns have been simulated for sewer systems (Pouzol et al, 2020), but investigations covering all the elements of an integrated urban wastewater system are still missing.…”

Modelling daily and hourly loads of pharmaceuticals in urban wastewater

“…As of today, it is not possible to compare the proposed model to other ones. The only model found in the literature that aimed to predict hourly loads of pharmaceuticals (Coutu et al, 2016) does not provide any criteria to assess the model performance. However, it seems to give results with rather similar accuracy and performance compared with our proposed model.…”

“…Schowanek and Webb (2002), Götz et al (2013) and Oldenkamp et al (2016) for example proposed models that investigate the spatial variably of pharmaceutical occurrence alongside rivers or across Europe. Various scales of temporal variations have also been modelled: long term variability linked to demographic evolution (Tränckner and Koegst, 2010), seasonal (Marx et al, 2015), daily (Gernaey et al, 2011;Snip et al, 2014) and hourly (Coutu et al, 2016) variability.…”

Mass spectrometric strategies for the investigation of biomarkers of illicit drug use in wastewater

“…In addition, intra‐day variations in wastewater flows require samples to be collected in a flow‐ or volume‐weighted manner. More details and peculiarities for wastewater sampling in sewers, an overview of relevant literature, and a list of requirements for a series of typical applications is described elsewhere (De Keyser et al, ; Ort et al, ,; Ort, ; Coutu et al, ).…”