Integrated Stent Delivery System: A Next Generation of Stent Delivery and Drug-Eluting Stent

Fischell, Tim A.; Balmuri, Abilash; Agarwal, Sourabh; Verhye, Stefan

doi:10.1016/j.carrev.2019.04.014

Cited by 4 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As the polymer coating also acts as the eluting drug’s reservoir, it must be non-thrombogenic, non-inflammatory, non-toxic to cells, and should encourage arterial healing by re-endothelialization [ 12 , 19 , 21 , 23 , 63 ]. In this respect, the adequate features of phosphorylcholine, polylactic acid, poly(vinylidencefluoride-co-hexafluoropropenen), and polyvinylpyrrolidone have attracted interest for stent coatings, mitigating inflammation and thrombosis risk [ 6 , 24 , 64 ]. Furthermore, there are many available techniques for fabricating polymer-coating stents that can be chosen from (e.g., dip-coating, electrospinning, spray coating, hot melt coating), depending upon the constitutional complexity of the stent platforms and their uncharacterized properties as medical devices [ 20 , 65 , 66 , 67 ].…”

Section: Evolution Of Cardiovascular Stentsmentioning

confidence: 99%

“…Years later, as a solution to these issues, the deployment of drug-eluting stents (DESs) became an integral treatment option for patients with coronary artery disease [ 23 ]. Coronary DESs not only revolutionized PCI treatment but have also been approved as the current standard as they significantly reduce restenosis of vascular stents and mitigate the need for repeat revascularizations [ 20 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

View full text Add to dashboard Cite

One of the leading causes of morbidity and mortality worldwide is coronary artery disease, a condition characterized by the narrowing of the artery due to plaque deposits. The standard of care for treating this disease is the introduction of a stent at the lesion site. This life-saving tubular device ensures vessel support, keeping the blood-flow path open so that the cardiac muscle receives its vital nutrients and oxygen supply. Several generations of stents have been iteratively developed towards improving patient outcomes and diminishing adverse side effects following the implanting procedure. Moving from bare-metal stents to drug-eluting stents, and recently reaching bioresorbable stents, this research field is under continuous development. To keep up with how stent technology has advanced in the past few decades, this paper reviews the evolution of these devices, focusing on how they can be further optimized towards creating an ideal vascular scaffold.

show abstract

Section: Evolution Of Cardiovascular Stentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

View full text Add to dashboard Cite

show abstract

“…An additional instance of structure advancement is the dealings of bifurcated stents that can withstand the challenge encountered in bifurcation procedures. Bifurcated PCI is linked with a high incidence of perioperative drawbacks, intra-stent restenosis, and stent thrombosis [ 24 ]. An assigned bifurcated stent can be selected for this method because the surgeon can place a stent in the lesion without rewiring the side area.…”

Section: Reviewmentioning

confidence: 99%

Cardiovascular Stents: Types and Future Landscape

Sahu,

Nashine,

Mudey

et al. 2023

Cureus

View full text Add to dashboard Cite

One of the prominent reasons for mortality and morbidity worldwide is coronary artery disease (CAD), an ailment that manifests itself by the narrowing of the artery with the deposition of plaque. The definitive mode of action for dealing with this condition is using a medical device known as a stent at the affected location. This extremely important tubular equipment helps tremendously with vessel support. It also helps by keeping the path of blood flow clear for the heart muscle masses, its crucial nutrients, and oxygen supply. Several generations of stents have been continuously developed to improve patient outcomes and reduce side effects post-stent implantation. As we move from bare metal stents (BMSs) to drug-eluting stents (DESs) and, more recently, to bioabsorbable stents, the research area continues to develop. The use of this biomedical device has increased the standard of living in many cases; therefore, it is much needed to work on the possible growth areas in the cardiovascular stents and improve them to such an extent that the patients suffering from cardiovascular ailments get to live a comfortable life. Most articles deal with stents that are available for current use and their various types. They also cover the topic of stent optimization, as it is one of the key factors in enhancing stent usability and plays a prominent role in optimizing stent placement in the vessels of the body. To keep in touch with advances in stent technology over the past few decades, this article reviews advances in the devices, working on how available stents can be optimized to create new stents.

show abstract

“…Os stents farmacológicos de segunda geração surgiram por meio de constantes atualizações nos dispositivos anteriores. Os stents dessa geração mantiveram a atividade antirrestenótica encontrada nos stents de primeira geração, e procuraram promover um melhor perfil de segurança, com uma redução do surgimento de episódios endoteliais associado a uma redução de reintervenções no vaso-alvo após realização do procedimento percutâneo (Fischell, Balmuri, Agarwal & Verhye, 2020).…”

Section: Stents Farmacológicos De Segunda Geraçãounclassified

Gerações de stents no tratamento da cardiopatia isquêmica

Ferreira¹,

Gusmão²,

Duarte³

et al. 2020

RSD

View full text Add to dashboard Cite

A Doença Arterial Coronariana predispõe o desenvolvimento de doenças isquêmicas cardíacas, sendo uma das principais causas de morbimortalidade em todo mundo. As intervenções coronarianas percutâneas revascularizam o miocárdio por meio da implantação de stents a fim de restabelecer o fluxo sanguíneo nas artérias afetadas. Devido à alta no uso desses dispositivos nos procedimentos percutâneos, bem como as limitações atualmente encontradas, como trombose de stent, reestenose e eventos cardíacos adversos, o objetivo do presente estudo foi analisar as publicações que tratam das diversas gerações de stents no tratamento da doença arterial coronariana, através de uma revisão literária, com busca nas bases Scielo, Pubmed e Sciencedirect. Os stents farmacológicos surgiram como uma alternativa mais segura e eficaz que os stents convencionais, reduzindo episódios de reestenose e eventos cardíacos adversos maiores. No entanto, um maior risco de trombose ligada ao seu uso foi observado. Assim, por meio de um aperfeiçoamento no design, bem como dos materiais utilizados na sua fabricação, diversas gerações de stents farmacológicos foram desenvolvidas, ampliando o acervo terapêutico. Apesar disso, novos estudos ainda são necessários para comprovar sua segurança a longo prazo.

show abstract

Integrated Stent Delivery System: A Next Generation of Stent Delivery and Drug-Eluting Stent

Cited by 4 publications

References 26 publications

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Cardiovascular Stents: Types and Future Landscape

Gerações de stents no tratamento da cardiopatia isquêmica

Contact Info

Product

Resources

About