Integrated Spatial Multi-Omics Study of Postmortem Brains of Alzheimer’s Disease
Yumiko Toyama,
Takashi Nirasawa,
Maho Morishima
et al.
Abstract:Pathological hallmark of Alzheimer’s disease (AD) is characterized by the accumulation and aggregation of amyloid β (Aβ) peptides into extracellular plaques of the brain. Clarification of the process of how soluble Aβ starts to assemble into amyloid fibrils is an essential step in elucidating the pathogenesis of AD. In our previous study, Aβ proteoforms including full-length Aβ40 and Aβ42/43 with N- and C-terminal truncated forms were visualized in postmortem brains from AD patients with matrix-assisted laser … Show more
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