Integrated single-dose kinome profiling data is predictive of cancer cell line sensitivity to kinase inhibitors
Chinmaya U. Joisa,
Kevin A. Chen,
Matthew E. Berginski
et al.
Abstract:Protein kinase activity forms the backbone of cellular information transfer, acting both individually and as part of a broader network, the kinome. Their central role in signaling leads to kinome dysfunction being a common driver of disease, and in particular cancer, where numerous kinases have been identified as having a causal or modulating role in tumor development and progression. As a result, the development of therapies targeting kinases has rapidly grown, with over 70 kinase inhibitors approved for use … Show more
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