Pore pressure prediction work is typically calibrated with pressure measurements from sands and log data from the adjoining shales. This is done because compaction effects on standard well logs are better preserved in shales than in sands. The prediction work assumes that sands and adjacent shales attain pressure equilibrium over geological time. To avoid lithologic effects on rock properties, calibration requires picking of similar shales from log data. Most commonly, clean end-member shales are picked. This paper addresses the issues encountered while picking shales for real-time pore pressure prediction (RTPPP) and the strategies to deal with these issues to confirm that changes in log measurements are related to variations in shale porosity and hence pore pressure.Various shale picking issues that could impact RTPPP are: a) inconsistency in shale picking approach during model building phase and RT monitoring; b) lithology effects from presence of silt, carbonates, gas silts and organic rich shales; c) RT data issues related to logging while drilling (LWD) tool calibration and differences between phase shift and attenuation resistivity; and, d) anomalous log response like low gamma ray and low resistivity shales.The strategies adopted to mitigate these potential issues are: a) use of consistent shale picking strategy in model building and RT monitoring phases; b) application of effective media models like HashinShtrikman lower bound inversion and linear clay-volume modulation for silt correction and use of cross-plots to delineate the gas silts, etc., c) appropriate choice of resistivity tool and log curves to provide best measures of formation properties for each hole section and; d) validation of shale picks with well behavior, cuttings data and geological interpretation.An optimized shale picking strategy integrated with well behaviour is imperative for predicting pore pressures within realistic bounds of uncertainty and for avoiding under/over prediction of pore pressures that in turn jeopardizes safe drilling.