Integrated DNA methylation analysis reveals a potential role for PTPRN2 in Marfan syndrome scoliosis
Zhen‐zhong Zheng,
Jing‐hong Xu,
Jia‐lin Chen
et al.
Abstract:BackgroundMarfan syndrome (MFS) is a rare genetic disorder caused by mutations in the Fibrillin‐1 gene (FBN1) with significant clinical features in the skeletal, cardiopulmonary, and ocular systems. To gain deeper insights into the contribution of epigenetics in the variability of phenotypes observed in MFS, we undertook the first analysis of integrating DNA methylation and gene expression profiles in whole blood from MFS and healthy controls (HCs).MethodsThe Illumina 850K (EPIC) DNA methylation array was used… Show more
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