Integrated risk–benefit analyses: Method development with folic acid as example

Hoekstra, Jeljer; Verkaik-Kloosterman, Janneke; Rompelberg, C.J.M.; Kranen, Henk van; Zeilmaker, Marco J.; Verhagen, Hans; Jong, Nynke de

doi:10.1016/j.fct.2007.10.015

Cited by 62 publications

(63 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Examples for RBAs directed at the food compound are those for folic acid (Hoekstra et al, 2008) and vitamin D (Berjia et al, 2014) (Fig. 4).…”

Section: The Risk-benefit Questionmentioning

confidence: 99%

“…If the balance between benefits and risks is unclear, the assessment has to be performed at a higher tier, including quantitative assessment. As part of the BRAFO project, a number of relevant riskbenefit studies that illustrate the usefulness of a tiered approach for RBAs have been performed (Hoekstra et al, 2008;Schütte et al, 2012;Verhagen et al, 2012b;Watzl et al, 2012). A specific software tool, QALIBRA, has been developed to facilitate the performance of quantitative assessments in the final tier Hoekstra, Fransen et al, 2013).…”

Section: The Development Of Risk-benefit Assessmentmentioning

confidence: 99%

“…Here, one type of categorisation is the level of aggregation: the risk-benefit question can be targeted at a food compound level (a nutrient, a chemical or microbiological contaminant), a food product level (e.g., fish) or a diet level (Hoekstra et al, 2008).…”

Section: The Risk-benefit Questionmentioning

confidence: 99%

“…The crucial initial step of an RBA is the definition of the risk-benefit question (Hoekstra et al, 2008) or problem definition (Boobis et al, 2013;Boué et al, 2015;EFSA, 2010a). The risk-benefit question is generally a comparison between two, or a series of, choices, alternative policies or courses of action, described in the form of scenarios (Boobis et al, 2013).…”

Section: The Risk-benefit Questionmentioning

confidence: 99%

See 3 more Smart Citations

Meeting the challenges in the development of risk-benefit assessment of foods

Nauta

Andersen

Pilegaard

et al. 2018

Trends in Food Science & Technology

View full text Add to dashboard Cite

A B S T R A C TBackground: Risk-benefit assessment (RBA) of foods aims to assess the combined negative and positive health effects associated with food intake. RBAs integrate chemical and microbiological risk assessment with risk and benefit assessment in nutrition. Scope and Approach: Based on the past experiences and the methodological differences between the underlying research disciplines, this paper aims to describe the recent progress in RBAs, identifying the key challenges that need to be addressed for further development, and making suggestions for meeting these challenges. Key Findings and Conclusions: Ten specific challenges are identified and discussed. They include the variety of different definitions and terminologies used in the underlying research disciplines, the differences between the "bottom-up" and the "top-down" approaches and the need for clear risk-benefit questions. The frequent lack of data and knowledge with their consequential uncertainties is considered, as well as the imbalance in the level of scientific evidence associated with health risks and benefits. The challenges that are consequential to the need of considering substitution issues are discussed, as are those related to the inclusion of microbiological hazards. Further challenges include the choice of the integrative health metrics and the potential scope of RBAs, which may go beyond the health effect. Finally, the need for more practical applications of RBA is stressed. Suggestions for meeting the identified challenges include an increased interdisciplinary consensus, reconsideration of methodological approaches and health metrics based on a categorisation of risk-benefit questions, and the performance of case studies to experience the feasibility of the proposed approaches.

show abstract

“…Examples for RBAs directed at the food compound are those for folic acid (Hoekstra et al, 2008) and vitamin D (Berjia et al, 2014) (Fig. 4).…”

Section: The Risk-benefit Questionmentioning

confidence: 99%

Section: The Development Of Risk-benefit Assessmentmentioning

confidence: 99%

Section: The Risk-benefit Questionmentioning

confidence: 99%

Section: The Risk-benefit Questionmentioning

confidence: 99%

See 2 more Smart Citations

Meeting the challenges in the development of risk-benefit assessment of foods

Nauta

Andersen

Pilegaard

et al. 2018

Trends in Food Science & Technology

View full text Add to dashboard Cite

show abstract

“…• Gluten-free diet -lack of data • Folate -already performed in Dutch project (Hoekstra, Verkaik-Kloosterman et al 2008 The following suggestions were not prioritized as the suggestions were thought to be too broad, and thus difficult to address in a constructive way:…”

Section: Medium Prioritymentioning

confidence: 99%