Abstract:Background
The prodromal phase of Parkinson's disease can reach 10–20 years, and clinically meaningful biomarkers associated with Parkinson's disease (PD) have not been developed based on biofluid samples. Here, we aimed to identify novel biofulid candidate biomarkers by integrating CSF and saliva proteomes in PD.
Methods
We used a high-throughput tandem mass spectrometry to analyze 120 CSF samples and 203 saliva samples. Weighted gene co-expression network analysis (WGCNA) were performed to determine the pr… Show more
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