Integrated polymer-based Mach-Zehnder interferometer label-free streptavidin biosensor compatible with injection molding

Bruck, Roman; Melnik, Eva; Müellner, Paul; Hainberger, Rainer; Lämmerhofer, Michael

doi:10.1016/j.bios.2011.02.042

Cited by 68 publications

(30 citation statements)

References 32 publications

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“…we should be able to detect 20-40 nm diameter particles. This also agrees with the calculated signal-to-background ratio, which predicts that the detection limit is close to 26.1 nm: r min = r 6 p /SBR max 1/6 = (60 ± 15 nm) 6 /147 1/6 = 26.1 ± 6.5 nm. This detection limit allows us to detect particles the size of single viruses.…”

Section: Decreased Background Signal By Use Of Crossed Polarizerssupporting

confidence: 89%

See 1 more Smart Citation

Detection of single nano-defects in photonic crystals between crossed polarizers

Grepstad¹,

Kaspar²,

Johansen³

et al. 2013

Opt. Express

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Abstract:We investigate, by simulations and experiments, the light scattering of small particles trapped in photonic crystal membranes supporting guided resonance modes. Our results show that, due to amplified Rayleigh small particle scattering, such membranes can be utilized to make a sensor that can detect single nano-particles. We have designed a biomolecule sensor that uses cross-polarized excitation and detection for increased sensitivity. Estimated using Rayleigh scattering theory and simulation results, the current fabricated sensor has a detection limit of 26 nm, corresponding to the size of a single virus. The sensor can potentially be made both cheap and compact, to facilitate use at point-of-care.

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Section: Decreased Background Signal By Use Of Crossed Polarizerssupporting

confidence: 89%

“…Mach-Zehnder interferometers [6,7], optical ring resonators [8,9], photonic crystal cavity resonators [10], and techniques exploiting local surface-plasmon-resonance (LSPR) in metal nano-particles are promising. Some are even reported to sense changes in refractive index corresponding to a single molecule [5,9,11,12].…”

Section: Introductionmentioning

confidence: 99%

Detection of single nano-defects in photonic crystals between crossed polarizers

Grepstad¹,

Kaspar²,

Johansen³

et al. 2013

Opt. Express

View full text Add to dashboard Cite

show abstract

“…Polymer Ormocore [17,18] is used as the waveguide core, which is on the SiO 2 under the cladding. The biological sample under test, namely the analyte, covers both sensing arms, which avoids etching an extra sensing pool [19,20]. Therefore, the complexity of the waveguide device fabrication is reduced, and the sensor array integration can be easily realized.…”

Section: Introductionmentioning

confidence: 99%

Polymer integrated waveguide optical biosensor by using spectral splitting effect

Han

Shao

et al. 2017

Photonic Sens

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Abstract:The polymer waveguide optical biosensor based on the Mach-Zehnder interferometer (MZI) by using spectral splitting effect is investigated. The MZI based biosensor has two unequal width sensing arms. With the different mode dispersion responses of the two-arm waveguides to the cladding refractive index change, the spectral splitting effect of the output interference spectrum is obtained, inducing a very high sensitivity. The influence of the different mode dispersions between the two-arm waveguides on the spectral splitting characteristic is analyzed. By choosing different lengths of the two unequal width sensing arms, the initial dip wavelength of the interference spectrum and the spectral splitting range can be controlled flexibly. The polymer waveguide optical biosensor is designed, and its sensing property is analyzed. The results show that the sensitivity of the polymer waveguide optical biosensor by using spectral splitting effect is as high as 10 4 nm/RIU, with an improvement of 2-3 orders of magnitude compared with the slot waveguide based microring biosensor.

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“…The rather simple structure and high sensitivity to refractive index changes make them attractive for sensing applications. MachZehnder-based strain [72], humidity [73], refractive index [74,75], and temperature sensors [76] were reported recently.…”

Section: Introductionmentioning

confidence: 99%

Optical temperature sensing on flexible polymer foils

et al. 2016

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Integrated polymer-based Mach-Zehnder interferometer label-free streptavidin biosensor compatible with injection molding

Cited by 68 publications

References 32 publications

Detection of single nano-defects in photonic crystals between crossed polarizers

Detection of single nano-defects in photonic crystals between crossed polarizers

Polymer integrated waveguide optical biosensor by using spectral splitting effect

Optical temperature sensing on flexible polymer foils

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