Integrated planar optical waveguide interferometer biosensors: A comparative review

Kozma, P.; Kehl, Florian; Ehrentreich‐Förster, Eva; Stamm, Christoph Georg; Bier, Frank F.

doi:10.1016/j.bios.2014.02.049

Cited by 273 publications

(205 citation statements)

References 114 publications

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“…This is made possible by employing an interferometric principle of operation in a Mach-Zehnder type optical setup. Although single wavelength (integrated) Mach-Zehnder interferometers (MZI) are widely employed for (bio-)chemical sensing, especially in the visible spectral range [17,18], a report on directly recording a liquid sample's absorption and dispersion spectrum in the Mid-IR using a MZI is, to the best of our knowledge, yet pending. The reader is, however, pointed to infrared spectroscopic ellipsometry [19] and dispersive Fourier transform spectroscopy [20,21,22] that were used in (far-) infrared spectroscopic measurements of the complex dielectric function, mostly in reflection measurements.…”

Section: 29 Page 2 Ofmentioning

confidence: 99%

A quantum cascade laser-based Mach–Zehnder interferometer for chemical sensing employing molecular absorption and dispersion

et al. 2018

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We employ a novel spectroscopic setup based on an external cavity quantum cascade laser and a Mach-Zehnder interferometer to simultaneously record spectra of absorption and dispersion of liquid samples in the mid-infrared. We describe the theory underlying the interferometric measurement and discuss its implications for the experiment. The capability of simultaneously recording a refractive index and absorption spectrum is demonstrated for a sample of acetone in cyclohexane. The recording of absorption spectra is experimentally investigated in more detail to illustrate the method's capabilities as compared to direct absorption spectroscopy. We find that absorption signals are recorded with strongly suppressed background, but with smaller absolute sensitivity. A possibility of optimizing the setup's performance by unbalancing the interferometer is presented.

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Section: 29 Page 2 Ofmentioning

confidence: 99%

A quantum cascade laser-based Mach–Zehnder interferometer for chemical sensing employing molecular absorption and dispersion

et al. 2018

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“…In the field of optical sensing and biomedical applications, mainly the potential for miniaturization and sensitivity improvement compared to state-of-the art systems adds to the attractiveness of integrated photonic solutions [14,15]. Nowadays, waveguide-based optical sensors reach the detection limit of 10 -7 /refractive index unit (RIU) [14], which covers most interesting applications.…”

Section: Introductionmentioning

confidence: 99%

TriPleX: a versatile dielectric photonic platform

Wörhoff

Heideman

Leinse

et al. 2015

Advanced Optical Technologies

207

175

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Photonic applications based on planar waveguide technology impose stringent requirements on properties such as optical propagation losses, light coupling to optical fibers, integration density, as well as on reliability and reproducibility. The latter is correlated to a high level of control of the refractive index and waveguide geometry. In this paper, we review a versatile dielectric waveguide platform, called TriPleX, which is based on alternating silicon nitride and silicon dioxide films. Fabrication with CMOS-compatible equipment based on low-pressure chemical vapor deposition enables the realization of stable material compositions being a prerequisite to the control of waveguide properties and modal shape. The transparency window of both materials allows for the realization of low-loss waveguides over a wide wavelength range (400 nm-2.35 μm). Propagation losses as low as 5 × 10 -4 dB/cm are reported. Three basic geometries (box shell, double stripe, and filled box) can be distinguished. A specific tapering technology is developed for on-chip, low-loss ( < 0.1 dB) spotsize convertors, allowing for combining efficient fiber to chip coupling with high-contrast waveguides required for increased functional complexity as well as for hybrid integration with other photonic platforms such as InP and SOI. The functionality of the TriPleX platform is captured by verified basic building blocks. The corresponding library and associated design kit is available for multi-project wafer (MPW) runs. Several applications of this platform technology in communications, biomedicine, sensing, as well as a few special fields of photonics are treated in more detail.

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“…Im Gegensatz zu markerbasierten Messmethoden wie z.B. Detektion über Fluoreszenzsignale benötigen die markerfreien Methoden keine weiteren Präpa-rationsschritte der Reagenzien [6]. Generell wird bei den markerfreien Methoden über einen Signalwandler, auf dessen Oberfläche Liganden zum Fangen der zu detektierenden Proteine immobilisiert sind, die Bindung der Proteine in ein messbares Signal umgewandelt.…”

Section: Introductionunclassified

Plattformtechnologie für die mobile, markerfreie Proteindetektion

Jahns

Neustock

Paulsen

et al. 2017

Tm - Technisches Messen

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ZusammenfassungWir präsentieren eine Plattformtechnologie zur mobilen, markerfreien Detektion von mehreren Proteinen gleichzeitig. Ein photonischer Kristall, der mit Liganden lokal funktionalisiert ist, dient hier als Sensor. Über ein kompaktes, Kamera-basiertes Messsystem wird die Proteinanbindung an die Sensoroberfläche in ein Intensitätssignal umgewandelt, über dessen Amplitude die Proteinkonzentration bestimmt werden kann. Um die Detektionsgrenze dieser Technologie weiter zu verbessern, werden hier photonische Kristalle mit einer multiperiodischen und aperiodischen Gitterstruktur simulativ und experimentell untersucht. Dafür werden die Gesamtempfindlichkeit und die Resonanzgüte jeder Struktur bestimmt und mit der bisher verwendeten monoperiodischen Struktur verglichen. Es konnte festgestellt werde, dass die Resonanzgüte von mono-über multi-bis aperiodisch sich deutlich verbessert. Eine Steigerung der Gesamtempfindlichkeit konnte nicht festgestellt werden. Jedoch konnte anhand von Analysen der elektrischen Feldverteilung innerhalb der verschiedenen Strukturen beobachtet werden, dass die Modenausbreitungen in den aperiodischen Strukturen stark lokalisiert wird und die -Funktionalisierung repräsentiert, liegt. Diese lokale Resonanzausbildung konnte zudem bereits in ersten experimentellen Untersuchungen bestätigt werden.

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Integrated planar optical waveguide interferometer biosensors: A comparative review

Cited by 273 publications

References 114 publications

A quantum cascade laser-based Mach–Zehnder interferometer for chemical sensing employing molecular absorption and dispersion

A quantum cascade laser-based Mach–Zehnder interferometer for chemical sensing employing molecular absorption and dispersion

TriPleX: a versatile dielectric photonic platform

Plattformtechnologie für die mobile, markerfreie Proteindetektion

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