“…Recently, such hotspots generated with different nano-architectures (shape, size, and ensembles/precise assemblies) presenting unique properties have been evaluated in the SPCE platform toward a variety of applications in the broad arena of photo-plasmonics. , This includes transformative technologies such as fluorescent polymer brushes and their growth, picomolar sensing of coronary heart disease biomarker lipoprotein-associated phospholipase A2 (LpPLA2), universal biochip sensors with a functional “molecular beacon”, monomer–higher aggregate energy transition, geometry switching of analytes, polymer light-emitting diodes, and multiplexing-based biosensors, to name a few. Notably, from extensive background research, it is observed that there are a few original studies that examine the prominence of bio-inspired nanohybrids synthesized via go-green approaches for generation of hotspots in the SPCE platform. , Moreover, very limited evidence is available on the systematic study of utilizing largely available sericin protein as a bio-inspired source for the synthesis of plasmonic nanohybrids. Conventionally, exorbitant, toxic, and corrosive capping and reducing agents (such as citrate, hydrazine, and sodium borohydride) are being employed for generating structurally and optically tunable nanomaterials, which in turn results in detrimental effects on the terrestrial and aquatic life systems. ,, In this regard, awareness toward green nanochemistry principles is growing rapidly in the physics, chemistry, and materials science as well as biosciences research community. − In light of these observations, in the current work, we developed a rapid, low-cost, frugal nano-engineering technique for the synthesis of plasmonic Ag, Au, and AgAu nanohybrids via a green approach.…”