Integrated pharmacokinetics of ginsenosides after intravenous administration of YiQiFuMai powder injection in rats with chronic heart failure by UFLC–MS/MS

Yiqi Fumai lyophilized injection attenuates doxorubicin-induced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis

“…Solutions were all kept at 4 C. 15,22 Accurately weighed YQFM (1.30 g) was dissolved in 30% methanol, and then pretreated with C8 solid-phase extraction (SPE) to remove interferences. 22 Firstly, the SPE was activated with methanol (10 mL) and followed by deionized water (10 mL). Secondly, the sample solution was added into SPE and the elution rate was 1 mL min À1 .…”

Proteomic Analysis Reveals the Protective Effects of Yiqi Fumai Lyophilized Injection on Chronic Heart Failure by Improving Myocardial Energy Metabolism

“…In addition, YQFM can regulate MAPKs and alleviate myocardial remodeling and heart failure caused by coronary artery ligation (CAL) (Pang et al, 2017). Many components of YQFM show mitochondrial regulation (Zheng et al, 2018), including ginsenosides Rb1, Rb3, Rg1, Rg3, Schisandra B, and Graphical Abstract | Potential mechanism of YQFM in the treatment of chronic heart failure is to improve myocardial energy metabolism via enhancing the mitochondrial function of myocardial.…”

“…In addition, YQFM can regulate MAPKs and alleviate myocardial remodeling and heart failure caused by coronary artery ligation (CAL) ( Pang et al, 2017 ). Many components of YQFM show mitochondrial regulation ( Zheng et al, 2018 ), including ginsenosides Rb1, Rb3, Rg1, Rg3, Schisandra B, and ophiopogon D ( Chiu et al, 2007 ; Chen and Ko, 2010 ; Sun et al, 2013 ; Mu et al, 2015 ; Dong et al, 2016 ; Chen et al, 2019 ; Park et al, 2019 ; Li et al, 2021 ). Nevertheless, the mechanism of YQFM in treating chronic heart failure remains to be further elucidated.…”

Ion mobility mass spectrometry with molecular modelling to reveal bioactive isomer conformations and underlying relationship with isomerization

“…Purification and characterization of these bioactive constituent is thus a quite challenging task . The ESI IM‐MS system is very helpful in this scenario because liquid chromatography (LC) can be directly coupled with this system for separation of complicated herbal medicines and the high sensitivity of MS makes the low concentration component analysis possible . In addition, IM increases the peak capacity, provides structural information and potential isomer separation .…”