Integrated paper-based sensing devices for diagnostic applications

Brunauer, Anna; Ates, H. Ceren; Dincer, Can; Früh, Susanna M.

doi:10.1016/bs.coac.2020.03.003

Cited by 12 publications

(5 citation statements)

References 91 publications

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“…Innovations in materials science, microfabrication, flexible microelectronic and microfluidics technology, the advances in the design and fabrication of electrochemical substrates, as well as the progress in miniaturized and flexible bioelectronics, and in different apps have enabled the development of electrochemical biosensors in new formats: ingestible, wearable, and implantable that allow the sensors to be carried on the own body or daily life devices (smartphones/watches) (Figure a). The versatility of current electrochemical substrates in terms of use (reusable or disposable , ), design, fabrication materials (paper, sustainable, edible, plastic, textile, and polymeric), and properties (superwettable, flexible, and stretchable) should be highlighted. Electrochemical affinity bioassays have also been successfully integrated into microfluidic (Figure b) and lateral flow (eLFA) devices (Figure c). , …”

Section: Key Alliances To Cover Important Routesmentioning

confidence: 99%

Electrochemical Affinity Biosensors: Pervasive Devices with Exciting Alliances and Horizons Ahead

Campuzano

Pingarrón

2023

ACS Sens.

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Electrochemical affinity biosensors are evolving at breakneck speed, strengthening and colonizing more and more niches and drawing unimaginable roadmaps that increasingly make them protagonists of our daily lives. They achieve this by combining their intrinsic attributes with those acquired by leveraging the significant advances that occurred in (nano)materials technology, bio(nano)materials and nature-inspired receptors, gene editing and amplification technologies, and signal detection and processing techniques. The aim of this Perspective is to provide, with the support of recent representative and illustrative literature, an updated and critical view of the repertoire of opportunities, innovations, and applications offered by electrochemical affinity biosensors fueled by the key alliances indicated. In addition, the imminent challenges that these biodevices must face and the new directions in which they are envisioned as key players are discussed.

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Section: Key Alliances To Cover Important Routesmentioning

confidence: 99%

Electrochemical Affinity Biosensors: Pervasive Devices with Exciting Alliances and Horizons Ahead

Campuzano

Pingarrón

2023

ACS Sens.

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“…For instance, the reflex tears generated during emotional or mechanical stimulation interfere with the basal tear-based sensing methodology, owing to the differences in composition and secretion rates of basal and reflex tears. Other potential challenges include the limited volume of basal tears (less than 5 µL) [ 81 ] produced by our eyes, and the need for a biocompatible, stable, energy-efficient, and miniaturized sensing platform with sufficiently high sensitivity and selectivity. These hurdles can be overcome through device miniaturization and biocompatible electronic interfaces.…”

Section: Non-invasively Accessible Resources For Biomarkersmentioning

confidence: 99%

Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders

Chung

Nguyen

Zhang

et al. 2022

Sensors

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Metabolic syndrome (MS) is a cluster of conditions that increases the probability of heart disease, stroke, and diabetes, and is very common worldwide. While the exact cause of MS has yet to be understood, there is evidence indicating the relationship between MS and the dysregulation of the immune system. The resultant biomarkers that are expressed in the process are gaining relevance in the early detection of related MS. However, sensing only a single analyte has its limitations because one analyte can be involved with various conditions. Thus, for MS, which generally results from the co-existence of multiple complications, a multi-analyte sensing platform is necessary for precise diagnosis. In this review, we summarize various types of biomarkers related to MS and the non-invasively accessible biofluids that are available for sensing. Then two types of widely used sensing platform, the electrochemical and optical, are discussed in terms of multimodal biosensing, figure-of-merit (FOM), sensitivity, and specificity for early diagnosis of MS. This provides a thorough insight into the current status of the available platforms and how the electrochemical and optical modalities can complement each other for a more reliable sensing platform for MS.

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“…It should be noted that the field of paper-based sensors is developing rapidly, and significant progress has been made in the development of such sensors. At present, quite a lot of reviews on paper-based sensors have already been published [ 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. But most of them are aimed at considering electrochemical and optical sensors, biosensors, gas sensors, and strain sensors.…”

Section: Introductionmentioning

confidence: 99%

Paper-Based Humidity Sensors as Promising Flexible Devices: State of the Art: Part 1. General Consideration

Korotcenkov

2023

Nanomaterials

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In the first part of the review article “General considerations” we give information about conventional flexible platforms and consider the advantages and disadvantages of paper when used in humidity sensors, both as a substrate and as a humidity-sensitive material. This consideration shows that paper, especially nanopaper, is a very promising material for the development of low-cost flexible humidity sensors suitable for a wide range of applications. Various humidity-sensitive materials suitable for use in paper-based sensors are analyzed and the humidity-sensitive characteristics of paper and other humidity-sensitive materials are compared. Various configurations of humidity sensors that can be developed on the basis of paper are considered, and a description of the mechanisms of their operation is given. Next, we discuss the manufacturing features of paper-based humidity sensors. The main attention is paid to the consideration of such problems as patterning and electrode formation. It is shown that printing technologies are the most suitable for mass production of paper-based flexible humidity sensors. At the same time, these technologies are effective both in the formation of a humidity-sensitive layer and in the manufacture of electrodes.

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Integrated paper-based sensing devices for diagnostic applications

Cited by 12 publications

References 91 publications

Electrochemical Affinity Biosensors: Pervasive Devices with Exciting Alliances and Horizons Ahead

Electrochemical Affinity Biosensors: Pervasive Devices with Exciting Alliances and Horizons Ahead

Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders

Paper-Based Humidity Sensors as Promising Flexible Devices: State of the Art: Part 1. General Consideration

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