Integrated Optical Sensor in a Digital Microfluidic Platform

Liu, Lin; Evans, R.D.; Jokerst, N.M.; Fair, Richard B.

doi:10.1109/jsen.2008.918717

Cited by 123 publications

(58 citation statements)

References 44 publications

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“…Digital microfluidic LoC technology offers a platform for developing diagnostic applications with the advantages of scaling down of the sizes, miniaturized volume of reagents, portability, increased automation, low power consumption, compatibility with mass manufacturing, and high throughput. To date, heterogeneously integrated photodetectors and polymer microresonators have been integrated with digital electrowetting microfluidics LoC systems [159][160][161]. A schematic of the reported microresonator integrated with a digital electrowetting microfluidic system is shown in Figure 5, with accompanying photomicrographs of the system components before integration.…”

Section: Integration Of Microresonator Sensors With Microfluidic Sampmentioning

confidence: 99%

Chip scale integrated microresonator sensing systems

Jokerst¹,

Royal

Palit

et al. 2009

Journal of Biophotonics

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Medicine, environmental monitoring, and security are application areas for miniaturized, portable sensing systems. The emerging integration of sensors with other components (electronic, photonic, fluidic) is moving sensing toward higher levels of portability through the realization of self-contained chip scale sensing systems. Planar optical sensors, and in particular, microresonator sensors, are attractive components for chip scale integrated sensing systems because they are small, have high sensitivity, can be surface customized, and can be integrated singly or in arrays in a planar format with other components using conventional semiconductor fabrication technologies. This paper will focus on the progress and prospects for the integration of microresonator sensors at the chip scale with photonic input/output components and with sample preparation microfluidics, toward self-contained, portable sensing systems.

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Section: Integration Of Microresonator Sensors With Microfluidic Sampmentioning

confidence: 99%

Chip scale integrated microresonator sensing systems

Jokerst¹,

Royal

Palit

et al. 2009

Journal of Biophotonics

Self Cite

View full text Add to dashboard Cite

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“…A typical DMFB consists of a bottom layer and a top layer [7]. For cyberphysical DMFBs, a photodetector (PD) for optical sensing can also be integrated into the top plate of the DMFB [8]; see Fig. 2.…”

Section: Overview Of Digital Microfluidicsmentioning

confidence: 99%

Advances in Design Automation Techniques for Digital-Microfluidic Biochips

Ibrahim

Chakrabarty

2015

Formal Modeling and Verification of Cyber-Physical Systems

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Abstract. Due to their emergence as an efficient platform for pointof-care clinical diagnostics, digital-microfluidic biochips (DMFBs) have received considerable attention in recent years. They combine electronics with biology, and they integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. In this chapter, we first present an overview of digital-microfluidic biochips. We next describe emerging computer-aided design (CAD) tools for the automated synthesis and optimization of biochips from bioassay protocols. The chapter includes solutions for fluidic-operation scheduling, module placement, droplet routing, and pin-constrained chip design. We also show how recent advances in the integration of sensors into a DMFB can be exploited to provide cyberphysical system adaptation based on feedback-driven control.

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“…Using a copper layer for the electrodes, solder mask as the insulator, and a Teflon AF coating for hydrophobicity, the microfluidic array can be fabricated using an existing PCB process. A typical coplanar digital microfluidic chip has an electrode pitch of 1.5 mm, with a gap of 90 [73]. Actuation voltages of around 220 V are applied for fluidic operation.…”

Section: B Digital Microfluidicsmentioning

confidence: 99%

Design Automation and Test Solutions for Digital Microfluidic Biochips

Chakrabarty

2010

IEEE Trans. Circuits Syst. I

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Abstract-Microfluidics-based biochips are revolutionizing high-throughput sequencing, parallel immunoassays, blood chemistry for clinical diagnostics, and drug discovery. These devices enable the precise control of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and they integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. Compared to conventional laboratory procedures, which are cumbersome and expensive, miniaturized biochips offer the advantages of higher sensitivity, lower cost due to smaller sample and reagent volumes, system integration, and less likelihood of human error. This tutorial paper provides an overview of droplet-based "digital" microfluidic biochips. It describes emerging computer-aided design (CAD) tools for the automated synthesis and optimization of biochips from bioassay protocols. Recent advances in fluidic-operation scheduling, module placement, droplet routing, pin-constrained chip design, and testing are presented. These CAD techniques allow biochip users to concentrate on the development of nanoscale bioassays, leaving chip optimization and implementation details to design-automation tools.

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Integrated Optical Sensor in a Digital Microfluidic Platform

Cited by 123 publications

References 44 publications

Chip scale integrated microresonator sensing systems

Chip scale integrated microresonator sensing systems

Advances in Design Automation Techniques for Digital-Microfluidic Biochips

Design Automation and Test Solutions for Digital Microfluidic Biochips

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