a b s t r a c tHigh interconnection density associated with current electronics products poses certain challenges in designing circuit boards. Methods, including laser-assisted microvia drilling and surface mount technologies for example, are being used to minimize the impacts of the problems. However, the bottleneck is significantly pronounced at bit data rates above 10 Gbit/s where losses, especially those due to crosstalk, become high. One solution is optical interconnections (OI) based on polymer waveguides. Laser ablation of the optical waveguides is viewed as a very compatible technique with ultraviolet laser sources, such as excimer and UV Nd:YAG lasers, being used due to their photochemical nature and minimal thermal effect when they interact with optical materials. In this paper, the authors demonstrate the application of grey relational analysis to determine the optimized processing parameters concerning fabrication of multimode optical polymer waveguides by using infra-red 10.6 mm CO 2 laser micromachining to etch acrylate-based photopolymer (Truemode ™ ). CO 2 laser micromachining offers a low cost and high speed fabrication route needed for high volume productions as the wavelength of CO 2 lasers can couple well with a variety of polymer substrates. Based on the highest grey relational grade, the optimized processing parameters are determined at laser power of 3 W and scanning speed of 100 mm/s.