Integrated neural interfaces

Abstract

Abstract-Electronic interfaces to the nervous system are increasingly important for experimental neuroscience as well as medical diagnostics and therapies. Existing neural interfaces are limited, however, by the use of passive recording and stimulation devices that are connected to active electronics on separate physical platforms through large amounts of passive wiring. This manuscript proposes a new approach to integrate active electronics directly with neural recording and stimulation devices using state-of-the-art silicon processing, assembly, and packaging techniques. System concepts are described for fully wireless operation as well as wireline interfacing through FDA-cleared implantable leads and connectors. The approach offers a more modular paradigm of neural interface design, which is greatly needed as the demand for higher channel counts grows.

Acquisition of Neural Action Potentials Using Rapid Multiplexing Directly at the Electrodes

“…The rapidly multiplexed acquisition approach is particularly well suited for high channel count microelectrode arrays, where active circuitry is integrated with the device through homogenous fabrication [ 15 , 19 , 25 ] or advanced heterogeneous approaches [ 29 , 60 , 61 ]. The technique in itself does not address interconnect limitations that arise when adopting headstage recording architectures where active circuits (chips) are connected to electrode arrays through standard printed circuit boards and connectors (i.e., not fully implantable) [ 3 , 4 , 5 ].…”