Integrated MRI-guided radiotherapy — opportunities and challenges

Keall, Paul J.; Brighi, Caterina; Glide-Hurst, Carri K; Liney, Gary; Liu, Paul Z Y; Lydiard, Suzanne; Paganelli, Chiara; Pham, Toan M.; Shan, Shanshan; Tree, A.; Heide, Uulke A. van der; Waddington, David E. J.; Whelan, Brendan

doi:10.1038/s41571-022-00631-3

Cited by 73 publications

(55 citation statements)

References 144 publications

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“…Additionally, advances in radiation treatments made using new technologies, such as intensity-modulated radiotherapy, stereotactic body radiotherapy, and MRI-guided radiotherapy, have significantly improved the efficacy of radiotherapy and reduced its toxicities [ 131 , 132 , 133 ]. In particular, metabolic radiotherapy is a type of radiotherapy treatment that is carried out by introducing radioactive compounds into the body.…”

Section: Discussionmentioning

confidence: 99%

Matrices and Affinity Ligands for Antibody Purification and Corresponding Applications in Radiotherapy

Xue

Fan

2022

Biomolecules

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Antibodies have become an important class of biological products in cancer treatments such as radiotherapy. The growing therapeutic applications have driven a demand for high-purity antibodies. Affinity chromatography with a high affinity and specificity has always been utilized to separate antibodies from complex mixtures. Quality chromatographic components (matrices and affinity ligands) have either been found or generated to increase the purity and yield of antibodies. More importantly, some matrices (mainly particles) and affinity ligands (including design protocols) for antibody purification can act as radiosensitizers or carriers for therapeutic radionuclides (or for radiosensitizers) either directly or indirectly to improve the therapeutic efficiency of radiotherapy. This paper provides a brief overview on the matrices and ligands used in affinity chromatography that are involved in antibody purification and emphasizes their applications in radiotherapy to enrich potential approaches for improving the efficacy of radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Matrices and Affinity Ligands for Antibody Purification and Corresponding Applications in Radiotherapy

Xue

Fan

2022

Biomolecules

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“…MRI-Linac systems, which provide imaging capabilities during a course of treatment and are rapidly being clinically deployed worldwide, offer a tangible opportunity to make biologically-adaptive MRI-guided radiotherapy the next frontier in personalized brain cancer radiatiotherapy. 47 …”

Section: Discussionmentioning

confidence: 99%

An investigation of the conformity, feasibility, and expected clinical benefits of multiparametric MRI-guided dose painting radiotherapy in glioblastoma

Brighi

Keall

Holloway

et al. 2022

Neuro-Oncology Advances

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Background New technologies developed to improve survival outcomes for glioblastoma (GBM) continue to have limited success. Recently, image-guided dose painting (DP) radiotherapy has emerged as a promising strategy to increase local control rates. In this study, we evaluate the practical application of a multiparametric MRI model of glioma infiltration for DP radiotherapy in GBM by measuring its conformity, feasibility and expected clinical benefits against standard of care treatment. Methods Maps of tumour probability were generated from perfusion/diffusion MRI data from 17 GBM patients via a previously developed model of GBM infiltration. Prescriptions for DP were linearly derived from tumour probability maps and used to develop dose optimised treatment plans. Conformity of DP plans to dose prescriptions was measured via a quality factor. Feasibility of DP plans was evaluated by dose metrics to target volumes and critical brain structures. Expected clinical benefit of DP plans was assessed by tumour control probability. The DP plans were compared to standard radiotherapy plans. Results The conformity of the dose painting plans was >90%. Compared to the standard plans, DP a) did not affect dose delivered to organs at risk; b) increased mean and maximum dose and improved minimum dose coverage for the target volumes; c) reduced minimum dose within the radiotherapy treatment margins; d) improved local tumour control probability within the target volumes for all patients. Conclusions A multiparametric MRI model of GBM infiltration can enable conformal, feasible and potentially beneficial dose painting radiotherapy plans.

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“…Functional MRI techniques, including diffusion- and perfusion-weighted MRI, magnetic resonance spectroscopy (MRS) and blood-oxygen level dependent (BOLD) MRI, allow quantification of several aspects of the tumour physiology [9] . Combining two or more functional MRI techniques – a concept known as multiparametric MRI (mpMRI) – provides a means to spatially characterise biological heterogeneity within the brain and could be used to guide radiotherapy dose escalation in regions of infiltrating tumour [9] , [10] , [11] , [12] , [13] .…”

Section: Introductionmentioning

confidence: 99%

Repeatability of radiotherapy dose-painting prescriptions derived from a multiparametric magnetic resonance imaging model of glioblastoma infiltration

Brighi

Verburg

Koh

et al. 2022

Physics and Imaging in Radiation Oncology

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Integrated MRI-guided radiotherapy — opportunities and challenges

Cited by 73 publications

References 144 publications

Matrices and Affinity Ligands for Antibody Purification and Corresponding Applications in Radiotherapy

Matrices and Affinity Ligands for Antibody Purification and Corresponding Applications in Radiotherapy

An investigation of the conformity, feasibility, and expected clinical benefits of multiparametric MRI-guided dose painting radiotherapy in glioblastoma

Repeatability of radiotherapy dose-painting prescriptions derived from a multiparametric magnetic resonance imaging model of glioblastoma infiltration

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