Integrated metagenomics and metabolomics analyses revealed biomarkers in β-casein A2A2-type cows
Jinyan Zhao,
Chuanchuan Wang,
Jiahuan Hu
et al.
Abstract:In Holstein cows, β-casein, one of the most critical proteins in milk, exists in two main genotypes, A1 and A2. Herein, 45 Holstein cows [categorized into three groups based on β-casein A1A1, A1A2, and A2A2 genotypes (N = 15)] with the same feeding management and litter size were enrolled to explore differences in rumen microflora and metabolites across various β-casein genotypes. Rumen fluids were collected for metagenomics and metabolomics analyses. Metabolomics and weighted gene co-expression network analys… Show more
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