Integrated meta-analysis, data mining, and animal experiments to investigate the efficacy and potential pharmacological mechanism of a TCM tonic prescription, Jianpi Tongmai formula, in depression

Xue, Dan; Zhang, Yuhui; Song, Zhujin; Xiao, Jie; Jia, Ruiting; Zhu, Aizhi

doi:10.1016/j.phymed.2022.154344

Cited by 4 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, our sensitivity test showed that CHM users still had a lower risk of all-cause mortality than non-CHM users in patients with the CNS infections. Studies have shown that CHMs and associated natural compounds may be beneficial for neurological impairment in HIV/AIDS through anti-cognitive decline via the promotion of blood circulation and attenuation of oxidative stress, as well as anti-neuroinflammation and anti-HIV (Han et al, 2011;Cheng et al, 2015;Lin et al, 2015;Esposito et al, 2016;Zhao et al, 2016;Lee et al, 2017;Adebiyi et al, 2018;Long F. Y. et al, 2018;Zhang et al, 2018;Zeng et al, 2019;Qu et al, 2021;Dong et al, 2022;Xu et al, 2022;Xue et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Chinese herbal medicine (CHM) has been used in patients with HIV/AIDS-related diseases (Tsai F. J. et al, 2017;Tsai et al, 2018;Sun et al, 2019;Ho et al, 2021;Jiang et al, 2022). CHMs and related natural compounds have been reported to have anti-cognitive, antineuroinflammatory, and anti-HIV activities (Han et al, 2011;Cheng et al, 2015;Esposito et al, 2016;Zhao et al, 2016;Lee et al, 2017;Adebiyi et al, 2018;Long F. Y. et al, 2018;Zhang et al, 2018;Zeng et al, 2019;Qu et al, 2021;Dong et al, 2022;Xu et al, 2022;Xue et al, 2022). These studies encourage the investigation of whether CHM could improve survival in patients with neurological diseases HIV/AIDS as a complementary therapy to conventional medicine.…”

Section: Introductionmentioning

confidence: 91%

See 1 more Smart Citation

Effect of Chinese herbal medicine therapy on risks of all-cause mortality, infections, parasites, and circulatory-related mortality in HIV/AIDS patients with neurological diseases

Chiou

Chou²,

Ho³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Introduction: Long-term living with human immunodeficiency virus (HIV) and/or antiretroviral therapy (ART) is associated with various adverse effects, including neurocognitive impairment. Heterogeneous neurocognitive impairment remains an important issue, affecting between 15–65% of human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) patients and resulting in work performance, safety, and health-related outcomes that have a heavy economic burden.Methods: We identified 1,209 HIV/AIDS patients with neurological diseases during 2010–2017. The Kaplan–Meier method, log-rank test, and Cox proportional hazards model were used to analyze 308 CHM users and 901 non-CHM users within this population. Major CHM clusters were determined using association rule mining and network analysis.Results and Discussion: Results showed that CHM users had a 70% lower risk of all-cause mortality (adjusted hazard ratio (aHR) = 0.30, 95% confidence interval (CI):0.16–0.58, p < 0.001) (p = 0.0007, log-rank test). Furthermore, CHM users had an 86% lower risk of infections, parasites, and circulatory-related mortality (aHR = 0.14, 95% confidence interval (CI):0.04–0.46, p = 0.001) (p = 0.0010, log-rank test). Association rule mining and network analysis showed that two CHM clusters were important for patients with neurological diseases. In the first CHM cluster, Huang Qin (HQ; root of Scutellaria baicalensis Georgi), Gan Cao (GC; root of Glycyrrhiza uralensis Fisch.), Huang Lian (HL; root of Coptis chinensis Franch.), Jie Geng (JG; root of Platycodon grandiflorus (Jacq.) A.DC.), and Huang Bai (HB; bark of Phellodendron amurense Rupr.) were identified as important CHMs. Among them, the strongest connection strength was identified between the HL and HQ. In the second CHM cluster, Suan-Zao-Ren-Tang (SZRT) and Ye Jiao Teng (YJT; stem of Polygonum multiflorum Thunb.) were identified as important CHMs with the strongest connection strength. CHMs may thus be effective in treating HIV/AIDS patients with neurological diseases, and future clinical trials are essential for the prevention of neurological dysfunction in the population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Effect of Chinese herbal medicine therapy on risks of all-cause mortality, infections, parasites, and circulatory-related mortality in HIV/AIDS patients with neurological diseases

Chiou

Chou²,

Ho³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…TCM has shown remarkable curative effect on complex diseases through multiple targets, multiple compounds and multiple ways (Qiao et al, 2021;Huang et al, 2023). In the research of modernization of TCM, many scholars have accumulated a large amount of pharmacological and action mechanism data of TCM and its prescriptions through AI technology, which provide valuable information resources for the clinical application of TCM prescriptions (Yang et al, 2020;Xiong et al, 2022;Xue et al, 2022). For example, Ding et Coptis chinensis [Ranunculaceae, Coptis chinensis Franch.]]…”

Section: Tcm Compatibility Mechanismmentioning

confidence: 99%

Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Zhou,

Shen,

Hou

2024

Front. Pharmacol.

View full text Add to dashboard Cite

Traditional Chinese medicine (TCM) is the practical experience and summary of the Chinese nation for thousands of years. It shows great potential in treating various chronic diseases, complex diseases and major infectious diseases, and has gradually attracted the attention of people all over the world. However, due to the complexity of prescription and action mechanism of TCM, the development of TCM industry is still in a relatively conservative stage. With the rise of artificial intelligence technology in various fields, many scholars began to apply artificial intelligence technology to traditional Chinese medicine industry and made remarkable progress. This paper comprehensively summarizes the important role of artificial intelligence in the development of traditional Chinese medicine industry from various aspects, including new drug discovery, data mining, quality standardization and industry technology of traditional Chinese medicine. The limitations of artificial intelligence in these applications are also emphasized, including the lack of pharmacological research, database quality problems and the challenges brought by human-computer interaction. Nevertheless, the development of artificial intelligence has brought new opportunities and innovations to the modernization of traditional Chinese medicine. Integrating artificial intelligence technology into the comprehensive application of Chinese medicine industry is expected to overcome the major problems faced by traditional Chinese medicine industry and further promote the modernization of the whole traditional Chinese medicine industry.

show abstract

“…At present, many Chinese herbs play an important role in alleviating depressive symptoms, and their active ingredients can affect neurotransmitter levels, regulate the neuroendocrine system, and improve psychological states (86). Notable herbs like plant…”

Section: Fmt In Alleviating Depression Via Beneficial Herbsmentioning

confidence: 99%

Current landscape of fecal microbiota transplantation in treating depression

Zhang,

Bi,

Zhang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Depression, projected to be the predominant contributor to the global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication and psychotherapy often fall short, prompting the pursuit of alternative interventions. Recent research has highlighted the significant role of gut microbiota in mental health, influencing emotional and neural regulation. Fecal microbiota transplantation (FMT), the infusion of fecal matter from a healthy donor into the gut of a patient, emerges as a promising strategy to ameliorate depressive symptoms by restoring gut microbial balance. The microbial-gut-brain (MGB) axis represents a critical pathway through which to potentially rectify dysbiosis and modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals and reduce inflammatory markers, thereby alleviating depressive behaviors. Moreover, FMT has shown promise in clinical settings, improving gastrointestinal symptoms and overall quality of life in patients with depression. The review highlights the role of the gut-brain axis in depression and the need for further research to validate the long-term safety and efficacy of FMT, identify specific therapeutic microbial strains, and develop targeted microbial modulation strategies. Advancing our understanding of FMT could revolutionize depression treatment, shifting the paradigm toward microbiome-targeting therapies.

show abstract

Integrated meta-analysis, data mining, and animal experiments to investigate the efficacy and potential pharmacological mechanism of a TCM tonic prescription, Jianpi Tongmai formula, in depression

Cited by 4 publications

References 24 publications

Effect of Chinese herbal medicine therapy on risks of all-cause mortality, infections, parasites, and circulatory-related mortality in HIV/AIDS patients with neurological diseases

Effect of Chinese herbal medicine therapy on risks of all-cause mortality, infections, parasites, and circulatory-related mortality in HIV/AIDS patients with neurological diseases

Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Current landscape of fecal microbiota transplantation in treating depression

Contact Info

Product

Resources

About