Integrated MEMS in package

2016 IEEE Healthcare Innovation Point-of-Care Technologies Conference (HI-POCT)

Papadimitriou

Evans

et al. 2016

In this paper a novel, commercially available Labon-Printed Circuit Board (LoPCB) manufacturing technology is demonstrated for the development of low-cost electrochemical biosensors combined with microfluidics for Point-of-Care (PoC) applications. An analysis of the developed PCB architecture is presented, detailing the three development areas of the proposed LoPCB platform, i.e. microfluidics, biosensors and electronics. Design rules and potential fabrication limitations are also discussed, based on the characterization of prototype fabricated systems. Two PCB-based devices have been designed and fabricated, a microfluidic active diluter with a variable and actively controlled dilution ratio and an electrochemical biosensor. Preliminary results obtained demonstrate the feasibility of a complete LoPCB platform, where all three compartments will co-exist and cooperate , providing an electronic-based PoC system for electrochemical biosensing.

Section: Introductionmentioning

confidence: 99%

The Lab-on-PCB framework for affordable, electronic-based point-of-care diagnostics: From design to manufacturing

2016 IEEE Healthcare Innovation Point-of-Care Technologies Conference (HI-POCT)

Papadimitriou

Evans

et al. 2016

“…the Lab-on-PCB [17]. Such as simple substrate is ideal for commercial upscaling of LoC devices, since it benefits from the high degree of electronics integration, high precision, and the accumulated experience of several decades of industrial manufacturing [13,18]. Examples of PCBbased devices include micromixers [17], nucleic acid amplification chips [19] and chemical sensors [20].…”

Section: Page 2 Ofmentioning

confidence: 99%

Long-lasting FR-4 surface hydrophilisation towards commercial PCB passive microfluidics

Applied Surface Science

Moschou

Carta

et al. 2016

Highlights oxygen plasma treatment on FR-4 laminates  effect of power and exposure time studied to achieve long-lasting hydrophilic properties  super-hydrophilic surface for 13 days demonstrated  surface remains weakly hydrophilic between 13 th and 26 th day after the treatment  hydrophilic behaviour is retained for 26 days in total  oxygen plasma treatment was used on a commercially manufactured PCB microfluidic chip to enable passive filling of a microfluidic network AbstractPrinted circuit boards (PCB) technologies are an attractive system for simple sensing and microfluidic systems. Controlling the surface properties of PCB material is an important part of this technology and to date there has been no study on long-term hydrophilisation stability of these materials. In this work, the effect of different oxygen plasma input power and treatment duration times on the wetting properties of FR-4 surfaces was investigated by sessile droplet contact angle measurements. Super and weakly hydrophilic behaviour was achieved and the retention time of these properties was studied, with the hydrophilic nature being retained for at least 26 days. To demonstrate the applicability of this treatment method, a commercially manufactured microfluidic structure made from a multilayer PCB (3-layer FR-4 stack) was exposed to oxygen plasma at the optimum conditions. The structures could be filled with deionised (DI) water under capillary flow unlike the virgin devices.

“…The combination of both, biochemistry and appropriate electronics on the same platform could reduce noise interference from the various electrical interconnections and as a result may improve the measurement’s signal-to-noise ratio (SNR) [ 35 ]. Finally, the high degree of electronics integration, the exceptional accuracy, and the accumulated experience and skills of a mature industrial manufacturing process highlight the great advantage to LoPCB platforms [ 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Modular Pressure and Flow Rate-Balanced Microfluidic Serial Dilution Networks for Miniaturised Point-of-Care Diagnostic Platforms

Papadimitriou

Morgan

et al. 2019

Sensors

Fast, efficient and more importantly accurate serial dilution is a necessary requirement for most biochemical microfluidic-based quantitative diagnostic applications. Over the last two decades, a multitude of microfluidic devices has been proposed, each one demonstrating either a different type of dilution technique or complex system architecture based on various flow source and valving combinations. In this work, a novel serial dilution network architecture is demonstrated, implemented on two entirely different substrates for validation and performance characterisation. The single layer, stepwise serial diluter comprises an optimised microfluidic network, where identical dilution ratios per stage are ensured, either by applying equal pressure or equal flow rates at both inlets. The advantages of this serial diluter are twofold: Firstly, it is structured as a modular unit cell, simplifying the required fluid driving mechanism to a single source for both sample and buffer solution. Thus, this unit cell can be used as a fundamental microfluidic building block, forming multistage serial dilution cascades, once combined appropriately with itself or other similar unit cells. Secondly, the serial diluter can tolerate the inevitable flow source fluctuations, ensuring constant dilution ratios without the need to employ damping mechanisms, making it ideal for Point of Care (PoC) platforms. Proof-of-concept experiments with glucose have demonstrated good agreement between simulations and measurements, highlighting the validity of our serial diluter.